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首页> 外文期刊>Occupational and environmental medicine >Occupational exposures and pancreatic cancer: a meta-analysis.
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Occupational exposures and pancreatic cancer: a meta-analysis.

机译：职业暴露与胰腺癌：一项荟萃分析。

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OBJECTIVES: Consolidation of epidemiological data on pancreatic cancer and worksite exposures. METHODS: Publications during 1969-98 were surveyed. Studies without verified exposures were excluded. Meta-analyses were conducted on data from 92 studies covering 161 populations, with results for 23 agents or groups of agents. With a standard format, five epidemiologists extracted risk estimates and variables of the structure and quality of each study. The extracted data were centrally checked. Random meta-models were applied. RESULTS: Based on 20 populations, exposure to chlorinated hydrocarbon (CHC) solvents and related compounds was associated with a meta-risk ratio (MRR) of 1.4 (95% confidence interval (95% CI) 1.0 to 1.8). Nickel and nickel compounds were considered in four populations (1.9; 1.2 to 3.2). Excesses were found also for chromium and chromium compounds (1.4; 0.9 to 2.3), polycyclic aromatic hydrocarbons (PAHs) (1.5; 0.9 to 2.5), organochlorine insecticides (1.5; 0.6 to 3.7), silica dust (1.4; 0.9 to 2.0), and aliphatic and alicyclic hydrocarbon solvents (1.3; 0.8 to 2.8). Evidence on pancreatic carcinogenicity was weak or non-positive for the following agents: acrylonitrile (1.1; 0.0 to 6.2); arsenic (1.0; 0.6 to 1.5); asbestos (1.1; 0.9 to 1.5); diesel engine exhaust (1.0; 0.9 to 1.3); electromagnetic fields (1.1; 0.8 to 1.4); formaldehyde (0. 8; 0.5 to 1.0); flour dust (1.1; 0.3 to 3.2); cadmium and cadmium compounds (0.7; 0.4 to 1.4); gasoline (1.0; 0.8 to 1.2); herbicides (1.0; 0.8 to 1.3); iron and iron compounds (1.3; 0.7 to 2.5); lead and lead compounds (1.1; 0.8 to 1.5); man-made vitreous fibres (1.0; 0.6 to 1.6); oil mist (0.9; 0.8 to 1.0); and wood dust (1.1; 0.9 to 2.5). The occupational aetiological fraction of pancreatic cancer was estimated at 12%. In a subpopulation exposed to CHC solvents and related compounds, it was 29%; to chromium and chromium compounds, 23%; to nickel and nickel compounds, 47%; to insecticides, 33%; and to PAHs, 33%. CONCLUSION: Occupational exposures may increase risk of pancreatic cancer. High quality studies are called for on interactions between occupational, environmental, and lifestyle factors as well as interactions between genes and the environment.
机译：目的：合并关于胰腺癌和工作场所暴露的流行病学数据。方法：对1969-98年间的出版物进行了调查。没有经过验证的暴露的研究被排除在外。对来自161个人群的92项研究的数据进行了荟萃分析，得出23种病原体或一组病原体的结果。五位流行病学家采用标准格式，提取了每项研究的风险估计以及结构和质量的变量。对提取的数据进行集中检查。应用随机元模型。结果：基于20个人群，暴露于氯代烃（CHC）溶剂和相关化合物与1.4的荟萃风险比（MRR）相关（95％置信区间（95％CI）1.0至1.8）。镍和镍化合物在四个族群中被考虑（1.9; 1.2至3.2）。铬和铬化合物（1.4; 0.9至2.3），多环芳烃（PAHs）（1.5; 0.9至2.5），有机氯杀虫剂（1.5; 0.6至3.7），二氧化硅粉尘（1.4; 0.9至2.0）也被发现过量。 ，以及脂族和脂环族烃溶剂（1.3; 0.8至2.8）。对于以下药物，胰腺癌致癌性证据微弱或呈阳性：丙烯腈（1.1; 0.0至6.2）;砷（1.0; 0.6至1.5）;石棉（1.1; 0.9至1.5）;柴油机排气（1.0; 0.9至1.3）;电磁场（1.1; 0.8至1.4）;甲醛（0. 8; 0.5至1.0）;面粉粉尘（1.1; 0.3至3.2）;镉和镉化合物（0.7; 0.4至1.4）;汽油（1.0; 0.8至1.2）;除草剂（1.0; 0.8至1.3）;铁和铁化合物（1.3; 0.7至2.5）;铅和铅化合物（1.1; 0.8至1.5）;人造玻璃纤维（1.0; 0.6至1.6）;油雾（0.9; 0.8至1.0）;和木屑（1.1; 0.9至2.5）。胰腺癌的职业病因学比例估计为12％。在暴露于CHC溶剂和相关化合物的亚人群中，这一比例为29％;铬和铬化合物为23％;镍和镍化合物占47％;杀虫剂占33％;对PAHs而言，占33％。结论：职业接触可能增加胰腺癌的风险。需要对职业，环境和生活方式因素之间的相互作用以及基因与环境之间的相互作用进行高质量的研究。

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