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Nonsteroidal anti-inflammatory drugs in early pregnancy.

机译：怀孕初期使用非甾体类抗炎药。

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A study was performed of congenital malformations in infants whose mothers used nonsteroidal anti-inflammatory drugs (NSAIDs) in early pregnancy. Data were obtained from an ongoing prospective recording of drug use during the first trimester. During the period July 1, 1995 through December 31, 1998, 2557 infants were born to women who reported the use of NSAIDs in early pregnancy. The OR (after consideration of maternal age, parity, and smoking habits) for any congenital malformation was 1.04 (95%CI 0.84-1.29), but the OR for cardiac defects reported to the Medical Birth Registry was 1.86 (1.32-2.62) based on 36 instances, and for orofacial clefts 2.61 (1.01-6.78) based on only six instances. By using other information sources, another four infants with cardiac defects were identified. There was no drug specificity for cardiac defects but among six mothers of infants with orofacial clefts, five had used naproxen.
机译：对母亲在妊娠早期使用非甾体类抗炎药（NSAIDs）的婴儿进行了先天性畸形的研究。数据来自前三个月的持续用药记录。在1995年7月1日至1998年12月31日期间，有2557名婴儿出生于报告称在早孕期使用非甾体抗炎药的妇女。先天性畸形的OR（考虑孕产妇年龄，性别和吸烟习惯）为1.04（95％CI 0.84-1.29），但向医学出生登记处报告的心脏缺陷的OR为1.86（1.32-2.62）在36个实例中，仅基于六个实例的口腔裂隙为2.61（1.01-6.78）。通过使用其他信息来源，确定了另外四名患有心脏缺陷的婴儿。没有针对心脏缺陷的药物特异性，但是在六名患有口面部裂痕的婴儿的母亲中，有五名使用了萘普生。

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