The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway

Dance M; Montagner A; Salles JP; Yart A; Raynal P

首页> 外文期刊>Cellular Signalling >The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway

【24h】

The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway

机译：Shp2在Ras /促分裂原活化蛋白激酶（ERK1 / 2）途径中的分子功能

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Shp2 is a ubiquitous tyrosine phosphatase containing Src Homology 2 domains which plays major biological functions in response to various growth factors, hormones or cytokines. This is essentially due to its particularity of promoting the activation of the Ras/Mitogen-activated protein kinase pathway. Recent progresses have been made in the understanding of the molecular mechanisms involved in this regulation. We review here, and discuss the physiological relevance, of the following molecular functions of Shp2 that have been proposed to couple the phosphatase to Ras activation: promoter of Grb2/Sos recruitment through direct binding to Grb2, binding partner and regulator of SHPS-I, negative regulator of Sprouty, negative regulator of RasGAP recruitment, and activator of Src through dephosphorylation of Src-regulatory proteins. (C) 2007 Elsevier Inc. All rights reserved.

机译：Shp2是一种普遍存在的酪氨酸磷酸酶，含有Src Homology 2结构域，对各种生长因子，激素或细胞因子具有重要的生物学功能。这主要是由于其促进Ras /丝裂原活化的蛋白激酶途径活化的特殊性。在理解该调控涉及的分子机制方面已取得了最新进展。我们在这里进行了综述，并讨论了已提出的将磷酸酶偶联至Ras活化的Shp2的以下分子功能的生理相关性：通过直接结合到Grb2的Grb2 / Sos募集启动子，SHPS-1的结合伴侣和调节剂， Sprouty的负调控因子，RasGAP募集的负调控因子，以及通过Src调控蛋白的去磷酸化来激活Src。（C）2007 Elsevier Inc.保留所有权利。

著录项

来源
《Cellular Signalling》 |2008年第3期|共7页
作者
Dance M; Montagner A; Salles JP; Yart A; Raynal P;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类细胞形态学;
关键词
Shp2; Ras; ERK1/2; Gab1; Src; RasGAP; Sprouty; SHPS; EPIDERMAL-GROWTH-FACTOR; TYROSINE-PHOSPHATASE SHP-2; SRC FAMILY KINASES; SIGNALING PATHWAY; RAS ACTIVATION; PHOSPHOTYROSINE PHOSPHATASE; GRB2-ASSOCIATED BINDER-1; FACTOR STIMULATION; SPROUTY PROTEINS; NOONAN-SYNDROME;

机译：Shp2;Ras;ERK1 / 2;Gab1;Src;RasGAP;Sprouty;SHPS;表皮生长因子;酪氨酸磷酸酶SHP-2;SRC家族激酶;信号通路;RAS活化;磷酸酪氨酸磷酸酯酶;GRB2-ASSOCIA-1因子刺激萌芽蛋白努南综合征;

相似文献

外文文献
中文文献
专利

1. The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway [J] . Dance M, Montagner A, Salles JP, Cellular Signalling . 2008,第3期

机译：Shp2在Ras /促分裂原活化蛋白激酶（ERK1 / 2）途径中的分子功能
2. cAMP Activates TRPC6 Channels via the Phosphatidylinositol 3-Kinase (PI3K)-Protein Kinase B (PKB)-Mitogen-activated Protein Kinase Kinase (MEK)-ERK1/2 Signaling Pathway [J] . Bing Shen, Hiu-Yee Kwan, Xin Ma, The Journal of biological chemistry . 2011,第22期

机译：CAMP通过磷脂酰肌醇3-激酶（PI3K）-PROTEIN激酶B（PKB） - 乳蛋白激活蛋白激酶激酶激酶（MEK）-ERK1 / 2信号传导通路来激活TRPC6通道
3. Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal-regulated kinase/mitogen-activated protein kinase and RhoA signaling pathways. [J] . Kontaridis MI, Yang W, Bence KK, Circulation: An Official Journal of the American Heart Association . 2008,第11期

机译：心肌细胞中Ptpn11（Shp2）的缺失通过对细胞外信号调节激酶/促分裂原活化蛋白激酶和RhoA信号通路的影响而引起扩张型心肌病。
4. Erk1/2 mitogen-activated protein kinase pathway involves in myostatin-regulated differentiation repression [C] . Wei Yang, Yan Chen, Yong Zhang, 中国遗传学会七届二次青年研讨会论文汇编 . 2006

机译：Erk1 / 2丝裂原激活的蛋白激酶途径参与肌生成抑制素调节的分化抑制。
5. Molecular interplay among the redox-responsive regulator AaAP1, the two-component histidine kinase and the mitogen-activated protein (MAP) kinases in Alternaria alternata of citrus. [D] . Lin, Ching-Hsuan. 2010

机译：氧化还原反应调节因子AaAP1，两组分组氨酸激酶和柑橘交链孢霉中丝裂原活化蛋白（MAP）激酶之间的分子相互作用。
6. cAMP Activates TRPC6 Channels via the Phosphatidylinositol 3-Kinase (PI3K)-Protein Kinase B (PKB)-Mitogen-activated Protein Kinase Kinase (MEK)-ERK1/2 Signaling Pathway [O] . Bing Shen, Hiu-Yee Kwan, Xin Ma, 2011

机译：cAMP通过磷脂酰肌醇3-激酶（PI3K）-蛋白激酶B（PKB）-丝裂原激活的蛋白激酶激酶（MEK）-ERK1 / 2信号通路激活TRPC6通道
7. cAMP Activates TRPC6 Channels via the Phosphatidylinositol 3-Kinase (PI3K)-Protein Kinase B (PKB)-Mitogen-activated Protein Kinase Kinase (MEK)-ERK1/2 Signaling Pathway* [O] . Shen, Bing, Kwan, Hiu-Yee, Ma, Xin, 2011

机译：cAMP通过磷脂酰肌醇3-激酶（PI3K）-蛋白激酶B（PKB）-促分裂原激活的蛋白激酶激酶（MEK）-ERK1 / 2信号通路激活TRPC6通道*

The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway

摘要

著录项

相似文献

相关主题

期刊订阅