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The roles of the Hippo pathway in cancer metastasis

机译:河马途径在癌症转移中的作用

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Cancer metastasis refers to the sequence of events whereby tumour cells detach from their primary tissue, invade and migrate to nearby vasculature, intravasate into circulation, survive in circulation and extravasate at a distant site to establish a secondary tumour. Each step in this "metastatic cascade" is coordinated by complex molecular events that remain only incompletely understood. Given that the vast majority of cancer fatalities occur due to metastasis, there is an urgent need for an improved understanding of the specific mechanisms underlying cancer metastasis and for the development of therapeutics targeting this lethal process.
机译:癌症转移是指肿瘤细胞从其主要组织脱离,侵入并迁移到附近的脉管系统,血管内进入循环,在循环中生存并在远处扩散以建立继发性肿瘤的一系列事件。此“转移级联”中的每个步骤都由复杂的分子事件协调,这些分子事件只是不完全被理解。鉴于绝大部分的癌症死亡是由于转移引起的,因此迫切需要对癌症转移的具体机制有更深入的了解,并且需要开发针对这种致死过程的疗法。

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