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首页> 外文期刊>Sarcoidosis, vasculitis, and diffuse lung diseases: official journal of WASOG >Chemokines and asthma.
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Chemokines and asthma.

机译：趋化因子和哮喘。

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摘要

Asthma is a complex disease resulting from a combination of factors including genetics, environmental exposure to allergens and prior infection with respiratory viruses. Worldwide, asthma is considered to be one of the leading causes of chronic childhood illness with young children living in poverty in urban environments being particularly severely affected. A common feature of the response to allergen challenge in asthmatic individuals is pattern of intense inflammation in the airways and a group of chemotactic cytokines, also known as chemokines, are believed to play a central role at multiple stages of this inflammatory response. Identification of the role of individual chemokines in the allergic response has been complicated by the diversity of chemokine production and the promiscuous pattern of chemokine-chemokine receptor interactions. However, chemokines have been shown to mediate the differential recruitment of leukocytes to the airways and regulate activation of both recruited and resident cells in the lungs. As the role of chemokines and their receptors at each stage of allergic inflammation become more clearly defined, it becomes increasingly likely that novel anti-inflammatory agents which modulate chemokine-chemokine receptor interactions will be developed and prove to be therapeutically beneficial.
机译：哮喘是一种复杂的疾病，是由多种因素共同导致的，包括遗传学，对过敏原的环境暴露以及先前感染过呼吸道病毒。在世界范围内，哮喘被认为是导致慢性儿童疾病的主要原因之一，城市环境中生活在贫困中的幼儿受到的影响尤为严重。哮喘个体对变应原攻击的反应的共同特征是气道中强烈的炎症模式，并且一组趋化性细胞因子（也称为趋化因子）被认为在该炎症反应的多个阶段起着核心作用。趋化因子产生的多样性和趋化因子与趋化因子受体相互作用的混杂模式使个体趋化因子在过敏反应中的作用的鉴定变得复杂。然而，趋化因子已显示出介导白细胞向呼吸道的差异募集并调节肺中募集和驻留细胞的活化。随着趋化因子及其受体在变应性炎症的每个阶段中的作用变得更加明确，越来越有可能开发出新的调节趋化因子-趋化因子受体相互作用的抗炎药，并证明对治疗有益。

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