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Register-based research on twins

机译：基于登记的双胞胎研究

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Introduction: The Danish Twin Registry (DTR) has for more than 50 years been based on surveys and clinical investigations and over the two last decades also on register linkage. Currently these two approaches are merged within Statistics Denmark. Research topics: Here we report on three major groups of register-based research in the DTR that used the uniqueness of twinning. First, we focus on the "long-term prognosis" of being a twin compared with being a singleton and show that Danish twins have health trajectories in adulthood similar to singletons, which is a result of interest for twins and their families as well as a test of the fetal origins hypothesis that states that fetal growth restriction has long-term health consequences. Secondly, we summarise some of the most important register-based "classical twin studies", e.g. heritability studies on lifespan and exceptional longevity. Finally, we illustrate how the co-twin control method in a register setting can be used to control for the effect of rearing environment and genetic factors in studies of the association between exposures and health. Conclusion: The spectrum of register-based twin studies is very wide and have changed in accordance with methodological and data resource developments.
机译：简介：丹麦双生子注册中心（DTR）已有50多年的历史了，它以调查和临床研究为基础，而在过去的20年中，也是基于注册机构的联系。目前，这两种方法已在丹麦统计局内合并。研究主题：在这里，我们报告了DTR中使用孪生的独特性的三大类基于寄存器的研究。首先，我们关注与单身相比双胞胎的“长期预后”，并表明丹麦双胞胎在成年后的健康状况与单身相似，这是双胞胎及其家人和双胞胎的兴趣所在。检验胎儿起源的假设，该假设指出胎儿生长受限会对健康产生长期影响。其次，我们总结了一些最重要的基于注册的“经典双生子研究”，例如关于寿命和超长寿命的遗传性研究。最后，我们说明了如何通过寄存器设置中的双胎控制方法来控制暴露和健康之间关系的研究中饲养环境和遗传因素的影响。结论：基于登记的孪生研究的范围非常广泛，并且随着方法论和数据资源的发展而变化。

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