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首页> 外文期刊>Scandinavian journal of public health >Studies based on the Danish Adoption Register: Schizophrenia, BMI, smoking, and mortality in perspective
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Studies based on the Danish Adoption Register: Schizophrenia, BMI, smoking, and mortality in perspective

机译：基于丹麦收养登记表的研究：精神分裂症，BMI，吸烟和死亡率

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Introduction: The genetic and familial environmental influences making up familial correlations in traits and familial aggregation of diseases may be disentangled by adoption studies. Thus, resemblance between the adoptee and the biological relatives indicates a contribution of the segregating gene they have in common, and resemblance between the adoptee and the rearing adoptive family members indicates influences of the shared family environment. The Danish Adoption Register includes information on all 14,425 non-familial adoptions of Danish children legally granted in Denmark from 1924 to 1947. Research topics: To illustrate the adoption study approach in research, we present results achieved in schizophrenia, body fatness, smoking, and mortality. Significantly higher prevalence of schizophrenia and related conditions were found in biological relatives to adoptees with schizophrenia than among biological relatives to adoptees without schizophrenia. Clear trends in body mass index of biological relatives and the weight of adoptees were found in several settings. A genetic influence on smoking habits were found within a generation. A moderate genetic influence on the mortality rate has been found. Conclusion: The Danish Adoption Register has contributed to the knowledge about environmental and genetic influence in various fields. Genetic influence on the risk of schizophrenia, body fatness, smoking habits, and on the mortality rate has been found.
机译：简介：收养研究可能无法确定遗传和家族环境对构成特质的家族相关性和疾病的家族聚集的影响。因此，被收养人和亲戚之间的相似之处表明他们共同拥有分离基因，而被收养人和抚养收养家庭成员之间的相似之处表明共享家庭环境的影响。丹麦收养登记册包含1924年至1947年在丹麦合法授予的所有14425例丹麦儿童的非家庭收养信息。研究主题：为了说明研究中的收养研究方法，我们介绍了精神分裂症，体脂，吸烟和死亡。与患有精神分裂症的被收养者相比，在精神亲属的生物学亲属中发现的精神分裂症和相关疾病患病率明显高于没有精神分裂症的被收养者的生物学亲属。在几种情况下，生物亲属的体重指数和被收养者的体重都有明显的趋势。在一代人中发现了对吸烟习惯的遗传影响。已经发现对死亡率有中等程度的遗传影响。结论：丹麦收养登记册为有关各个领域的环境和遗传影响的知识做出了贡献。已经发现遗传对精神分裂症风险，身体脂肪，吸烟习惯和死亡率的影响。

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