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Noninvasive ventilation for patients with hypoxemic acute respiratory failure

机译:低氧血症急性呼吸衰竭患者的无创通气

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摘要

Noninvasive ventilation (NIV) has an established efficacy to improve gas exchange and reduce the work of breathing in patients with hypoxemic acute respiratory failure. The clinical efficacy in terms of meaningful outcome is less clear and depends very much on patient selection and assessment of the risks of the technique. The potential risks include an insufficient reduction of the oxygen consumption of the respiratory muscles in case of shock, an excessive increase in tidal volume in case of lung injury, and a risk of delayed or emergent intubation. With a careful selection of patients and a rapid decision regarding the need for intubation in case of failure, great benefits can be offered to patients. Emerging indications include its use in patients with treatment limitations, in the postoperative period, and in patients with immunosuppression. This last indication will necessitate reappraisal because the prognosis of the conditions associated with immunosuppression has improved over the years. In all cases, there is both a time window and a severity window for NIV to work, after which delaying endotracheal intubation may worsen outcome. The preventive use of NIV seems promising in this setting but needs more research. An emerging interesting new option is the use of high flow humidified oxygen, which seems to be intermediate between oxygen alone and NIV.
机译:无创通气(NIV)在改善低氧血症性急性呼吸衰竭患者的气体交换和减少呼吸工作方面具有确定的功效。就有意义的结果而言,临床疗效尚不清楚,并且在很大程度上取决于患者的选择和对该技术风险的评估。潜在的风险包括在休克情况下呼吸肌的氧气消耗减少量不足,在肺部受伤的情况下潮气量过度增加以及插管延迟或紧急出气的风险。通过对患者进行仔细选择并在失败的情况下迅速决定是否需要插管,可以为患者带来巨大的好处。新兴适应症包括其在治疗受限的患者,术后期以及免疫抑制患者中的使用。由于免疫抑制相关疾病的预后多年来已经改善,因此最后的适应症需要重新评估。在所有情况下,NIV都需要一个时间窗口和一个严重性窗口,之后延迟气管插管可能会使预后恶化。在这种情况下,预防性使用NIV似乎很有希望,但需要更多的研究。一个新兴的有趣的新选择是使用高流量加湿氧气,这似乎仅在氧气和NIV之间。

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