• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Modern rheumatology >Safety and response to influenza vaccine in patients with systemic-onset juvenile idiopathic arthritis receiving tocilizumab
【24h】

Safety and response to influenza vaccine in patients with systemic-onset juvenile idiopathic arthritis receiving tocilizumab

机译：接受Tocilizumab治疗的系统性青少年特发性关节炎患者的流感疫苗安全性和反应

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective We investigated the safety and efficacy of administering influenza vaccines to patients with systemiconset juvenile idiopathic arthritis (sJIA) treated with tocilizumab. Patients and methods The subjects were 27 sJIA patients treatedwith tocilizumab and 17 healthy age- and sex-matched volunteers. Serum samples were collected prior to and 4-7 weeks after vaccination. Hemagglutination inhibition values of the vaccine were taken as the antibody titers. The duration of tocilizumab administration and the daily doses of prednisolone per unit body weight were analyzed to identify factors affecting the responses of the sJIA patients to influenza vaccination. We questioned all the subjects about whether they had contracted influenza and whether they had had adverse reactions to the influenza vaccination. We compared steroid doses in sJIA patients before and after vaccination to document any worsening of the underlying disease. Results The efficacy of influenza vaccination did not differ significantly between the sJIA group and the healthy controls. The duration of tocilizumab administration did not affect the response of the sJIA patients to the influenza vaccination. None of the sJIA patients experienced either severe adverse reactions or disease exacerbation after the influenza vaccination. Conclusion We found that sJIA patients treated with tocilizumab could be effectively and safely immunized with the influenza vaccine.
机译：目的我们研究了对使用妥珠单抗治疗的系统概念性幼年特发性关节炎（sJIA）患者使用流感疫苗的安全性和有效性。患者和方法研究对象为27例接受托珠单抗治疗的sJIA患者和17名年龄和性别匹配的健康志愿者。在接种前和接种后4-7周收集血清样品。疫苗的血凝抑制值作为抗体效价。分析了托珠单抗的给药时间和单位体重泼尼松龙的每日剂量，以识别影响sJIA患者对流感疫苗接种反应的因素。我们向所有受试者询问他们是否感染了流感以及他们是否对流感疫苗接种产生了不良反应。我们比较了接种疫苗前后sJIA患者中的类固醇剂量，以记录潜在疾病的恶化情况。结果sJIA组和健康对照组之间的流感疫苗接种效果没有显着差异。给予托珠单抗的持续时间不影响sJIA患者对流感疫苗的反应。接种流感疫苗后，没有任何sJIA患者出现严重的不良反应或疾病恶化。结论我们发现用托珠单抗治疗的sJIA患者可以有效，安全地接种流感疫苗。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号