...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Surgical Endoscopy >Inflammatory impact of NOTES peritoneoscopy is not different from that of laparoscopy: A randomized comparative study in a survival porcine model
【24h】

Inflammatory impact of NOTES peritoneoscopy is not different from that of laparoscopy: A randomized comparative study in a survival porcine model

机译：NOTES腹膜镜与腹腔镜对炎症的影响没有区别：在生存猪模型中的随机比较研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Inflammatory changes of different NOTES approaches remain unknown. The aim of this study was to compare the inflammatory effects of NOTES and laparoscopy. Methods: Forty female pigs were assigned to transgastric, transrectal, and transvaginal NOTES and laparoscopic peritoneoscopy groups. Antiseptic technique was utilized for NOTES whereas laparoscopy was performed sterile. Intraperitoneal pressures were monitored and maintained below 15 mmH 2O. Pneumoperitoneum was maintained with CO 2 in all groups. Pre- and postoperative blood samples of IL-6, Il-1β, and TNFα, and peritoneal fluid collected at surgery were analyzed. Animals were followed daily for 14 days. At necropsy, peritoneal fluid was collected for cytokine analysis. Results: Thirty-nine peritoneoscopies were successfully completed. The median procedure time was longer in the NOTES groups (57 min, range = 33-109) than in the laparoscopy group (33 min, range 32-36; P 0.001); this was related to longer incision time and closure time. All 39 completed follow-up. Severe bleeding in the post-transrectal approach required early sacrifice of the remaining animal. Besides this, complications were similar among groups. At necropsy, adhesions were seen in four animals in the gastric group, five in the rectal group, two in the vaginal group, and two in the laparoscopic group (P = ns). There were no statistical differences in serum levels of TNFα among the groups. When serum TNFα values were expressed as the difference from the baseline, in the transvaginal group they were significantly lower than in the transrectal at 2 h [0.5 pg/ml (range = -14 to 59) vs. 60 pg/ml (range = -8 to 303); P = 0.041] and at 8 h [-5.5 pg/ml (range = -86 to 55] vs. 37 pg/ml (range = -30 to 62); P = 0.031]. The limitations of this study were that the analyses of IL-6 and Il-1β were not possible because most of the samples were below detectable levels, it was an animal model, and the sample size was small. Conclusion: Inflammatory parameters are similar between NOTES and laparoscopic peritoneoscopy despite longer surgery time in the NOTES group. The vaginal route seems to reduce the inflammatory stress.
机译：背景：不同NOTES方法的炎症变化仍然未知。这项研究的目的是比较NOTES和腹腔镜检查的炎症作用。方法：将40头雌猪分为胃，腹腔镜和腹腔镜腹膜镜检查组。防腐技术用于NOTES，而腹腔镜检查则无菌进行。监测腹膜内压力并维持在15mmH 2 O以下。在所有组中，气腹维持CO 2维持。分析了术前和术后的IL-6，II-1β和TNFα的血液样本以及手术中收集的腹膜液。每天跟踪动物14天。尸检时，收集腹膜液用于细胞因子分析。结果：成功完成了39例腹膜镜检查。 NOTES组的中位手术时间（57分钟，范围= 33-109）比腹腔镜检查组（33分钟，范围32-36; P <0.001）更长。这与更长的切口时间和闭合时间有关。全部39例完成随访。经直肠后方法严重出血需要尽早杀死剩余的动物。除此之外，各组之间的并发症相似。尸检时，胃组有四只动物，直肠组有五只，阴道组有两只，腹腔镜组有两只（P = ns）。各组之间的血清TNFα水平无统计学差异。当血清TNFα值表示为与基线的差异时，经阴道组在2 h时显着低于经直肠组[0.5 pg / ml（范围= -14至59）与60 pg / ml（范围= -8至303）; P = 0.041]和在8小时时[-5.5 pg / ml（范围= -86至55）与37 pg / ml（范围= -30至62）; P = 0.031]。 IL-6和Il-1β的分析无法进行，因为大多数样品都低于可检测水平，这是一个动物模型，并且样品量很小结论：尽管手术时间较长，但NOTES和腹腔镜腹膜镜检查的炎症参数相似在NOTES组中，阴道途径似乎可以减轻炎症压力。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号