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Impact of Roux-en-Y gastric bypass on regulation of diabetes type 2 in morbidly obese patients

机译：Roux-en-Y胃旁路术对病态肥胖患者2型糖尿病的调节作用

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Background: The idea of surgery as treatment for type 2 diabetes mellitus (T2DM) was established in the US and was based on observation of patients after bariatric surgery. Resolution of T2DM is observed within a few weeks after surgery, in some cases even during hospitalization. The aim of this study was to evaluate the impact of Roux-en-Y gastric bypass (RYGB) on diabetes in morbidly obese patients. Methods: We present 73 patients with T2DM who underwent laparoscopic RYGB (LRYGB) to treat morbid obesity. In the group of 73 obese patients (mean BMI = 42.3), there were 41 females and 32 males. Results Regression of T2DM was observed in 51 patients (69.8%) while hospitalized. In addition, 14 patients' (19.1%) glycemia and HBA1c stabilized within 12 weeks after surgery (total regression rate of 88.9%). Conclusion: The ultimate evaluation of this method of treating T2DM is still lacking and requires several years of meticulous clinical studies. Despite that, considering the high cost of life-long conservative therapy of T2DM and its complications and the severe impact T2DM has on quality of life, surgical metabolic intervention may become the most reasonable solution in many cases.
机译：背景：在美国建立了手术治疗2型糖尿病（T2DM）的想法，该想法基于对减肥手术患者的观察。在手术后的几周内，甚至在住院期间，都可以观察到T2DM的消退。这项研究的目的是评估Roux-en-Y胃搭桥术（RYGB）对病态肥胖患者糖尿病的影响。方法：我们对73例接受腹腔镜手术RYGB（LRYGB）治疗病态肥胖的T2DM患者进行了研究。在73例肥胖患者（平均BMI = 42.3）中，女性41例，男性32例。结果住院期间51例患者（69.8％）观察到T2DM消退。此外，有14位患者（19.1％）的血糖和HBA1c在手术后12周内趋于稳定（总消退率为88.9％）。结论：仍缺乏对这种治疗T2DM方法的最终评估，并且需要数年的精心临床研究。尽管如此，考虑到T2DM的终身保守治疗的高昂费用及其并发症，以及T2DM对生活质量的严重影响，在许多情况下，外科手术代谢干预可能成为最合理的解决方案。

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