The First Measles Vaccine

Jeffrey P. Baker

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The First Measles Vaccine

机译：第一麻疹疫苗

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Like in the more familiar story of polio vaccine, the development of the first successful live attenuated vaccine against measles began in the laboratory of John Enders. One of the greatest virologists of the 20th century, Enders pioneered the technique of viral tissue culture, which makes it possible to grow viruses in vitro in cells nourished in laboratory media. In 1949, he and his pediatric infectious disease fellows Thomas Weller and Frederick Robbins showed that poliovirus could be cultivated in tissue of nonneuronal origins, a discovery that set the stage for the first successful vaccines against the disease and led to a Nobel Prize in 1954.

机译：就像在更熟悉的脊髓灰质炎疫苗故事中一样，第一个成功的麻疹减毒活疫苗的研制始于约翰·恩德斯的实验室。作为20世纪最伟大的病毒学家之一，恩德斯开创了病毒组织培养技术，该技术使在实验室培养基中培养的细胞中体外培养病毒成为可能。 1949年，他和他的儿科传染病研究人员Thomas Weller和Frederick Robbins表明，脊髓灰质炎病毒可以在非神经源性组织中培养，这一发现为成功针对该疾病的首批疫苗奠定了基础，并于1954年获得了诺贝尔奖。

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《Pediatrics: Official Publication of the American Academy of Pediatrics》 |2011年第3期|共3页
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Jeffrey P. Baker;
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1. Randomized Trials Comparing Inactivated Vaccine After Medium- or High-titer Measles Vaccine With Standard Titer Measles Vaccine After Inactivated Vaccine A Meta-analysis [J] . Aaby Peter, Ravn Henrik, Benn Christine S., The Pediatric infectious disease journal . 2016,第11期

机译：比较中，高滴度麻疹疫苗后灭活疫苗与标准滴度麻疹疫苗后灭活疫苗的随机试验荟萃分析
2. Aerosolized measles and measles-rubella vaccines induce better measles antibody booster responses than injected vaccines: randomized trials in Mexican schoolchildren. [J] . Bennett JV, Fernandez de Castro J, Valdespino Gomez JL, Bulletin of the World Health Organization . 2002,第10期

机译：气雾化的麻疹和麻疹风疹疫苗比注射的疫苗诱导出更好的麻疹抗体加强反应：墨西哥学童的随机试验。
3. Co-administration of live measles and yellow fever vaccines and inactivated pentavalent vaccines is associated with increased mortality compared with measles and yellow fever vaccines only An observational study from Guinea-Bissau [J] . Fisker Ane Baerent, Ravn Henrik, Rodrigues Amabelia, Vaccine . 2014,第5期

机译：与仅麻疹和黄热病疫苗相比，活麻疹和黄热病疫苗以及灭活的五价疫苗的共同给药与死亡率增加相关。几内亚比绍的一项观察性研究
4. Pre-and Post vaccine Measles Antibody Levels in Infants: An Evaluation of Routine Immunization in Nigeria [C] . Fowotade A., Nwabuisi C., Bakare R.A., World Congress of the World Society for Pediatric Infectious Diseases . 2014

机译：婴儿的前后疫苗麻疹抗体水平：尼日利亚常规免疫的评价
5. Assessing trends in measles epidemiology, immunization coverage, vaccine efficacy, and cost-effectiveness to identify practical strategies for measles elimination in the Democratic Republic of Congo. [D] . Doshi, Reena Hemendra. 2014

机译：评估麻疹流行病学，免疫接种覆盖率，疫苗效力和成本效益的趋势，以确定在刚果民主共和国消除麻疹的实用策略。
6. Vaccination against measles: clinical trial of live measles vaccine given alone and live vaccine preceded by killed vaccine. Second report to the medical research council by the measles vaccines committee. [O] . 1968

机译：麻疹疫苗：单独接种活麻疹疫苗和先接种活疫苗再接种灭活疫苗的临床试验。麻疹疫苗委员会向医学研究理事会提交的第二份报告。
7. Vaccination against measles: clinical trial of live measles vaccine given alone and live vaccine preceded by killed vaccine. Second report to the medical research council by the measles vaccines committee. [O] . 1968

机译：麻疹疫苗：单独接种活麻疹疫苗和先接种活疫苗再接种灭活疫苗的临床试验。麻疹疫苗委员会向医学研究理事会提交的第二份报告。

The First Measles Vaccine

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