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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Clitoria ternatea and the CNS.
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Clitoria ternatea and the CNS.

机译：Clitoria ternatea和中枢神经系统。

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The present investigation was aimed at determining the spectrum of activity of the methanolic extract of Clitoria ternatea (CT) on the CNS. The CT was studied for its effect on cognitive behavior, anxiety, depression, stress and convulsions induced by pentylenetetrazol (PTZ) and maximum electroshock (MES). To explain these effects, the effect of CT was also studied on behavior mediated by dopamine (DA), noradrenaline, serotonin and acetylcholine. The extract decreased time required to occupy the central platform (transfer latency, TL) in the elevated plus maze (EPM) and increased discrimination index in the object recognition test, indicating nootropic activity. The extract was more active in the object recognition test than in the EPM. The extract increased occupancy in the open arm of EPM by 160% and in the lit box of the light/dark exploration test by 157%, indicating its anxiolytic activity. It decreased the duration of immobility in tail suspension test (suggesting its antidepressant activity), reduced stress-induced ulcers and reduced the convulsing action of PTZ and MES. The extract exhibited tendency to reduce the intensity of behavior mediated via serotonin and acetylcholine. The effect on DA- and noradrenaline-mediated behavior was not significant. In conclusion, the extract was found to possess nootropic, anxiolytic, antidepressant, anticonvulsant and antistress activity. Further studies are necessary to isolate the active principle responsible for the activities and to understand its mode of action.
机译：本研究旨在确定Clitoria ternatea（CT）甲醇提取物对CNS的活性谱。研究了CT对戊戊四唑（PTZ）和最大电击（MES）引起的认知行为，焦虑，抑郁，压力和惊厥的影响。为了解释这些影响，还研究了CT对多巴胺（DA），去甲肾上腺素，血清素和乙酰胆碱介导的行为的影响。提取物减少了在高架迷宫（EPM）中占据中央平台所需的时间（传输延迟，TL），并在对象识别测试中增加了辨别指数，表明其具有促智活性。提取物在对象识别测试中比在EPM中更活跃。提取物在EPM的开放臂中的占有率增加了160％，在明/暗探索测试的灯箱中的占有率增加了157％，表明其具有抗焦虑作用。它减少了尾部悬吊测试中固定的持续时间（表明其抗抑郁活性），减少了压力诱发的溃疡并降低了PTZ和MES的惊厥作用。提取物表现出降低通过5-羟色胺和乙酰胆碱介导的行为强度的趋势。对DA和去甲肾上腺素介导的行为的影响不明显。总之，发现该提取物具有促智，抗焦虑，抗抑郁，抗惊厥和抗应激活性。有必要进行进一步的研究以分离出负责活动的主动原则并了解其作用方式。

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