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The role of the cannabinoid system in nicotine addiction.

机译:大麻素系统在尼古丁成瘾中的作用。

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摘要

Nicotine, the main psychoactive component in tobacco smoke, appears to play a major role in tobacco addiction, producing a high morbidity and mortality in the world. A great amount of research has been developed to elucidate the neural pathways and neurotransmitter systems involved in such a complex addictive behaviour. One possible candidate is the cannabinoid system, which has been reported to participate in the addictive properties of other drugs of abuse. This review is focused on the recent pharmacological and molecular studies assessing cannabinoid-nicotine interactions, with special attention to those studies evaluating the behavioural responses related to the development of nicotine addiction.
机译:尼古丁是烟草烟雾中的主要精神活性成分,似乎在烟草成瘾中起着重要作用,在世界范围内引起很高的发病率和死亡率。为了阐明这种复杂的成瘾行为的神经通路和神经递质系统,已经进行了大量研究。一种可能的候选药物是大麻素系统,据报道该系统参与了其他滥用药物的成瘾性。这篇综述的重点是最近评估大麻素-烟碱相互作用的药理和分子研究,尤其是那些评估与尼古丁成瘾发展有关的行为反应的研究。

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