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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The novel cannabinoid CB1 antagonist AM6545 suppresses food intake and food-reinforced behavior.
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The novel cannabinoid CB1 antagonist AM6545 suppresses food intake and food-reinforced behavior.

机译：新型大麻素CB1拮抗剂AM6545抑制食物摄入和食物强化行为。

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摘要

Drugs that interfere with cannabinoid CB1 transmission suppress food-motivated behaviors, and may be useful clinically as appetite suppressants. However, there may also be undesirable side effects (e.g., nausea, malaise, anxiety, and depression) that are produced by the current generation of CB1 inverse agonists such as rimonabant and taranabant. For that reason, it is important to continue research on novel cannabinoid antagonists. The present studies examined the effects of the novel compound AM6545, which is a neutral antagonist of CB1 receptors that is thought to have relatively poor penetrability into the central nervous system. Intraperitoneal administration of AM6545 significantly reduced food-reinforced operant responding at doses of 4.0, 8.0 and 16.0 mg/kg. AM6545 also produced a strong suppression of the intake of high-carbohydrate and high-fat diets in the same dose range, but only produced a mild suppression of lab chow intake at the highest dose (16.0 mg/kg). Although AM6545 did not affect food handling, it did reduce time spent feeding and feeding rate. Taken together, these results suggest that AM6545 is a compound that warrants further study as a potential appetite suppressant drug.
机译：干扰大麻素CB1传播的药物可抑制食物刺激行为，并且在临床上可作为食欲抑制剂。但是，当前一代的CB1反向激动剂（如利莫那班和taranabant）也可能会产生不良的副作用（例如恶心，不适，焦虑和沮丧）。因此，重要的是继续研究新型大麻素拮抗剂。本研究检查了新型化合物AM6545的作用，该化合物是CB1受体的中性拮抗剂，被认为对中枢神经系统的渗透性较差。腹膜内施用AM6545可以显着降低4.0、8.0和16.0 mg / kg剂量的食物强化操作应答。在相同的剂量范围内，AM6545还可以强烈抑制高碳水化合物和高脂肪饮食的摄入，但是在最高剂量（16.0 mg / kg）时，只能轻微抑制实验室食物的摄入。尽管AM6545不会影响食物处理，但确实可以减少进食时间和进食速度。综上所述，这些结果表明AM6545是一种有潜力作为抑制食欲的药物，值得进一步研究。

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