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Modeling complexity in biology

机译:在生物学中建模复杂性

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摘要

Biological systems, unlike physical or chemical systems, are characterized by the very inhomogeneous distribution of their components. The immune system, in particular, is notable for self-organizing its structure. Classically; the dynamics of natural systems have been described using differential equations. But, differential equation models fail to account for the emergence of large-scale inhomogeneities and for the influence of inhomogeneity on the overall dynamics of biological systems. Here, we show that a microscopic simulation methodology enables us to model the emergence of large-scale objects and to extend the scope of mathematical modeling in biology. We take a simple example from immunology and illustrate that the methods of classical differential equations and microscopic simulation generate contradictory results. Microscopic simulations generate a more faithful approximation of the reality of the immune system. (C) 2001 Elsevier Science B.V. All rights reserved. [References: 11]
机译:与物理或化学系统不同,生物系统的特征是其成分分布非常不均匀。免疫系统尤其以自组织其结构而著称。经典的使用微分方程描述了自然系统的动力学。但是,微分方程模型无法解释大规模不均匀性的出现以及不均匀性对生物系统整体动力学的影响。在这里,我们证明了微观仿真方法使我们能够对大型物体的出现进行建模,并扩展了生物学中数学建模的范围。我们从免疫学中举一个简单的例子,说明经典的微分方程和微观模拟的方法产生了矛盾的结果。微观模拟可以更真实地逼近免疫系统的现实。 (C)2001 Elsevier Science B.V.保留所有权利。 [参考:11]

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