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首页> 外文期刊>Photochemical & photobiological sciences: the official journal of the European Photochemistry Association and the European Society for Photobiology >Photodynamic therapy for unresectable cholangiocarcinoma: contribution of single operator cholangioscopy for targeted treatment
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Photodynamic therapy for unresectable cholangiocarcinoma: contribution of single operator cholangioscopy for targeted treatment

机译：不可切除胆管癌的光动力疗法：单人胆管镜对靶向治疗的贡献

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Photodynamic therapy (PDT) for unresectable cholangiocarcinoma is associated with improvement in cholestasis and survival. Single operator cholangioscopy (SOC) has been used for targeted laser illumination. We analyzed our growing experience of SOC with direct PDT. This is a retrospective analysis of a consecutive series of patients prospectively entered into a registry. Forty-five patients (24 male, aged 67.3 + 10.6 years) were treated with PDT for cholangiocarcinoma during a five-year period. Thirty-two patients were treated with ERCP and PDT alone, and 13 were treated with ERCP and PDT using SOC. The two groups were then compared to observe any statistically significant difference in regards to age, gender, serum bilirubin, MELD score, adverse effects, or survival. An overall median of 1 PDT session per patient (range: 1-9) was performed. Twenty-six total sessions of PDT using SOC were performed in 13 patients with a median of 2.0 sessions per patient (range: 1-6). Median global survival was 168 days (range: 26-1353). Median survival for the PDT-only group was 200 days, and median survival for the PDT-with-SOC group was 386 days (p = 0.45). There was a statistically significant difference (p < 0.0001) between the two groups in regards to fluoroscopy time, with the PDT-only group having a median time of 21.1 min and the PDT-with-SOC group having a median time of 11.1 min. PDT related complications included 7 cases of mild phototoxicity and one case of moderate phototoxicity requiring hospitalization. SOC permits targeted therapy during PDT and can be successfully performed without adverse events while simultaneously reducing exposure to radiation.
机译：不可切除的胆管癌的光动力疗法（PDT）与胆汁淤积和生存期改善有关。单操作胆道镜检查（SOC）已用于目标激光照射。我们分析了我们在直接PDT方面不断增长的SOC经验。这是对预期进入注册表的连续系列患者的回顾性分析。在五年期间，对PDT治疗胆管癌的患者有45名（24名男性，年龄为67.3 + 10.6岁）。单独使用ERCP和PDT治疗32例患者，使用SOC进行ERCP和PDT治疗13例。然后将两组进行比较，以观察到在年龄，性别，血清胆红素，MELD评分，不良反应或生存方面的任何统计学显着差异。每位患者总共进行了1次PDT疗程的中位数（范围：1-9）。在13位患者中，使用SOC总共进行了26场PDT疗程，每位患者的中位数为2.0疗程（范围：1-6）。全球生存中位数为168天（范围：26-1353）。仅PDT组的中位生存期为200天，PDT-SOC组的中位生存期为386天（p = 0.45）。在荧光检查时间方面，两组之间存在统计学上的显着差异（p <0.0001），其中仅PDT组的中位时间为21.1分钟，PDT-SOC组的中位时间为11.1分钟。 PDT相关并发症包括7例轻度光毒性和1例需要住院的中度光毒性。 SOC可在PDT期间进行有针对性的治疗，并且可以成功进行，而无不良事件，同时减少了辐射。

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