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Utility of Partition Coefficients in Dermal Model Development for Rat and GuineaPig

机译：分区系数在大鼠和豚鼠皮肤模型开发中的应用

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The ability to extrapolate usable dermal penetration data from one species toanother is fundamental to specific applications in risk assessment. The goal of this work is to quantitatively explain the movement of chemicals across the dermal barrier in differing species. The chemical absorbed during the exposure in amount per time per area (mg/hr/cm(2)) is defined as the flux of the chemical. In order to estimate the total amount of chemical absorbed during the exposure, a physiologically-based pharmacokinetic (PBPK) model can be used if appropriate physiological and kinetic parameters are known. A primary data requirement of PBPK models is the partition coefficients for the chemical in blood and each of the tissue groups that display distinct kinetic behavior. In this study, blood, muscle, liver, and fat harvested from male Fischer 344 rats and male Hartley guinea pigs were exposed to four test chemicals. Using a vial equilibration method, the tissue:air partition coefficient was determined for Chloropentafluorobenzene (CPFB), 1,2-Dichlorobenzene (DCB), 1-Iodoheptafluoropropane (C(3)F(7)I) and Perfluorohexyl Iodide (C(6)F(13)I). The tissue:air partition coefficients generated in this study covered a four order magnitude range and were incorporated into PBPK models that were used for describing species differences in organic chemical absorption through the dermal barrier.

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