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Quantitative Structure Activity Relationships of Chlorinated Alicyclic Compounds

机译：氯化脂环族化合物的定量构效关系

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A quantitative structure-activity relationship study was performed on 33chlorinate alicyclic compounds, most of which are chlorinated cyclodiene insecticides or their structural analogs. Their action on the t-butylbicyclophosphorothionate (TBPS) binding site of the gammaaminobutyric acid (GABA) receptor/chloride ionophore complex is being correlated with their lipophilicity, electronegativity and/or molecular connectivity characteristics. The biological parameters were investigate at Mississippi State University. The in vitro potency of the test compounds to compete with 33S tbps for binding to rat brain membranes was studied. Also the potency of the test compounds to inhibit 36Cl-flux into rat brain vesicles is being studied. The three chemical parameters were investigated at Iowa State University. Nuclear magnetic resonance was used to evaluate the electronic character of the alicyclic hydrocarbons being studied. Partition coefficients were determined for the series of compounds. Topological characteristics were elucidated using molecular connectivity indices.

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作者
Chambers, J. E.;
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年度 1995
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总页数 35
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Toxicity; Insecticides; Metabolites; Acids; Electronics; Nuclear magneticresonance; Degradation; Biology; Brain; Rats; Chemicals; Parameters; Structural properties; Sites; In vitro analysis; Topology; Coefficients; Membranes; Analogs; Potency; Mississippi;

机译：毒性;杀虫剂;代谢产物;酸;电子;核magneticresonance;降解;生物;脑;大鼠;化工;参数;结构性能;网站;在体外分析;拓扑;系数;膜;类似物;效能;密西西比州;

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Quantitative Structure Activity Relationships of Chlorinated Alicyclic Compounds

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