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Synthesis of Antidotes and Prophylactics for Organophosphorus Acetylcholinesterase Inhibitors.

机译：有机磷乙酰胆碱酯酶抑制剂的解毒剂和预防药物的合成。

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Work has been completed on 4-substituted and 6-substituted N,N- Dimethylcarbaaoyloxy derivatives in the imidazo 1,2-Apyridinium series (six new compounds). Previously four 8-substituted compounds had been prepared. Work has been begun on the 7-substituted series. In each series the goal is to prepare the parent compound and three 2-substituted analogs containing methyl, isopropyl and phenyl substituents. In vitro biological assays have been performed on all available derivatives (eleven compounds). The 4- and 8-substituted analogs are more active than the 6-substituted compounds.

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作者
Sundberg, R. J.;
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年度 1995
页码 1-24
总页数 24
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Synthesis; Acetylcholinesterase; Organophosphates; Biology; In vitro analysis; Isomers; Antidotes; Assaying; Cholinesterase inhibitors; Phenols; Organic phosphorus compounds; Preventive medicine; Propanols;

机译：合成;乙酰胆碱酯酶;有机磷酸酯;生物学;体外分析;异构体;解毒剂;测定;胆碱酯酶抑制剂;酚类;有机磷化合物;预防医学;丙醇;

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专利

1. Rat brain acetylcholinesterase activity: developmental profile and maturational sensitivity to carbamate and organophosphorus inhibitors. [J] . Mortensen SR, Hooper MJ, Padilla S Toxicology: An International Journal Concerned with the Effects of Chemicals on Living Systems . 1998,第1期

机译：大鼠脑乙酰胆碱酯酶活性：对氨基甲酸酯和有机磷抑制剂的发育概况和成熟敏感性。
2. One-Pot Synthesis of NEMP, a VX Surrogate, and Reactivation of NEMP-Inhibited Electrophorus Eel Acetylcholinesterase by Current Antidotes [J] . Cavalcante Samir F. A., Kitagawa Daniel A. S., Rodrigues Rafael B., Journal of the Brazilian Chemical Society . 2019,第5期

机译：NEMP，VX替代品的单壶合成，NEMP抑制电泳鳗鱼乙酰胆碱酯酶的再活化
3. One-Step Facile Synthesis of Nitrogen-Doped Carbon Dots: A Ratiometric Fluorescent Probe for Evaluation of Acetylcholinesterase Activity and Detection of Organophosphorus Pesticides in Tap Water and Food [J] . Huang Shan, Yao Jiandong, Chu Xu, Journal of Agricultural and Food Chemistry . 2019,第40期

机译：氮气掺杂碳点的一步性合成：用于评价乙酰胆碱酯酶活性的比例荧光探针和自来水和食物中有机磷农药的检测
4. A theoretical study of the interactions of acetylcholinesterase, irreversible inhibitors, and their antidotes [C] . S. C. Moldoveanu, V. A. Voicu, C. Mircioiu, NATO advanced research workshop on antidotes, protectors and decorporators-a new approach in the area of disarmament: From military towards environmental purpose . 1999

机译：乙酰胆碱酯酶，不可逆抑制剂及其抗蚀剂相互作用的理论研究
5. Synthesis and kinetic evaluation of chimeric acetylcholinesterase inhibitors. [D] . Cavanaugh, Kathryn Renee. 2009

机译：嵌合乙酰胆碱酯酶抑制剂的合成和动力学评估。
6. Correction: Rational design synthesis and evaluation of uncharged smart bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase. [O] . Lukas Gorecki, Oksana Gerlits, Xiaotian Kong, 2020

机译：校正：合理设计合成和评估有机磷酸盐抑制的人乙酰胆碱酯酶的不带电荷的智能双肟解毒剂。
7. Progress in Antidotes (Acetylcholinesterase Reactivators) Against Organophosphorus Pesticides [O] . Kamil Musilek, Ondrej Holas, Anna Horova, 2011

机译：对有机磷农药的解毒剂（乙酰胆碱酯酶蛋白反应剂）的进展
8. Synthesis of Antidotes and Prophylactics for Organophosphorus Acetylcholinesterase Inhibitors. [R] . Sundberg, R. J., Van Nguyen, P. 1994

机译：有机磷乙酰胆碱酯酶抑制剂的解毒剂和预防药物的合成。

Synthesis of Antidotes and Prophylactics for Organophosphorus Acetylcholinesterase Inhibitors.

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