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首页> 美国政府科技报告 >Seroepizootiology of Helicobacter pylori Gastric Infection in Nonhuman PrimatesHoused in Social Environments
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Seroepizootiology of Helicobacter pylori Gastric Infection in Nonhuman PrimatesHoused in Social Environments

机译：非人灵长类动物幽门螺杆菌胃感染的血清学研究在社会环境中的应用

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We determined the seroepizootiology of Helicobacterpylori infection in rhesusmonkeys. Plasma was obtained from 196 animals (age range, 1 to 22 years) that were housed in social environments, either in indoor gang cages, in outdoor corrals, or in free-ranging forested conditions. Plasma immunoglobulin G levels were determined with a specific enzyme-linked immunosorbent assay, and the cutoff immunoglobulin G value for H. pylori seropositivity was determined from a study of 25 monkeys whose infection status was assessed by light microscopy and culture. One-year-old animals of both genders in all housing conditions had the lowest rate of positivity (60% in monkeys 1 year old versus 81% in monkeys 2 to 10 years old, P = 0.026). In addition, females tended to have higher rates of positivity than males. Seroconversion during a 1-year observation period occurred in 7 (28%) of 25 seronegative animals. Seroreversion occurred in 3 (4%) of the 78 positive animals; all 3 of these animals had received antimicrobial agents during the year. These observations demonstrate that the epizootiology of H. pylori infection in rhesus monkeys may serve as a model for human infection.

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