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Correlation of Real-Time Catecholamine Release and Cytosolic CA2+ at SingleBovine Chromaffin Cells

机译：单次嗜铬细胞中实时儿茶酚胺释放与细胞内Ca2 +的相关性

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Previous investigations of the role of Ca2+ in stimulus-secretion coupling havebeen undertaken in populations of adrenal chromaffin cells. In the present study, the simultaneous detection of intracellular Ca2+, with the fluorescent probe fura-2, and catecholamine release, using a carbon-fiber microelectrode, are examined at single chromaffin cells in culture. Results from classic depolarizing stimuli, high potassium (30-140 mM) and 1,1-dimethyl-4-phenylpiperazinium (DMPP) (3-50 uM), show a dependence of peak cytosolic Ca2+ concentration and catecholamine release on secretagogue concentration. Catecholamine release induced by transient high K+ stimulation increases logarithmically with K+ concentration. Continuous exposure to veratridine (50 uM) induces oscillations in intracellular Ca2+, and at higher concentrations (100 uM) concomitant fluctuation of cytosolic Ca2+ and

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作者
Finnegan, J. M.; Wightman, R. M.;
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年度 1995
页码
总页数 32
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Calcium; Microelectronics; Catecholamines; Detection; Real time; Mobilization; Chemical properties; Cells; Population; Concentration(Composition); Release; Synchronism; Bovines; Potassium; Oscillation; Caffeine; Secretion; Chromium compounds; Adrenal glan;

机译：钙;微电子学;儿茶酚胺;检测;实时;动员;化学特性;细胞;群体;浓度（组成）;释放;同步;牛;钾;振荡;咖啡因;分泌;铬化合物;肾上腺;

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1. Gap junctions mediate electrical signaling and ensuing cytosolic Ca2+ increases between chromaffin cells in adrenal slices: A role in catecholamine release. [J] . Martin AO, Mathieu MN, Chevillard C, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2001,第15期

机译：间隙连接介导电信号传导并随之增加肾上腺切片中嗜铬细胞之间的胞质Ca2 +增加：在儿茶酚胺释放中的作用。
2. Agonist-dependent patterns of cytosolic Ca2+ changes in single bovine adrenal chromaffin cells: relationship to catecholamine release. [J] . K A Stauderman, M M Murawsky, R M Pruss Cell Regulation . 1990,第9期

机译：单个牛肾上腺嗜铬细胞胞质钙离子变化的激动剂依赖性模式：与儿茶酚胺释放的关系。
3. Inhibition by SEA0400, a selective inhibitor of Na+/Ca2+ exchanger, of Na+ -dependent Ca2+ uptake and catecholamine release in bovine adrenal chromaffin cells. [J] . Soma S, Kuwashima H, Matsumura C, Journal of pharmacological sciences. . 2006,第1期

机译：通过SEA0400（一种Na + / Ca2 +交换剂的选择性抑制剂）抑制牛肾上腺嗜铬细胞中Na +依赖的Ca2 +吸收和儿茶酚胺的释放。
4. Control of catecholamine release from chromaffin tissue in a teleost fish [C] . T. ABRAHAMSSON, S. NILSSON International Conference on Comparative Physiology . 1978

机译：从紧邻鱼类中的硫蛋白组织中的儿茶酚胺释放的控制
5. Non-thermal effects of pulsed microwave fields on catecholamine release from chromaffin cells: Exposure system design and characterization, and experimental data. [D] . Yoon, Jihwan. 2008

机译：脉冲微波场对嗜铬细胞释放儿茶酚胺的非热效应：曝光系统设计与表征以及实验数据。
6. Gap Junctions Mediate Electrical Signaling and Ensuing Cytosolic Ca2+ Increases between Chromaffin Cells in Adrenal Slices: A Role in Catecholamine Release [O] . Agnès O. Martin, Marie-Noëlle Mathieu, Claude Chevillard, 2001

机译：间隙连接介导的电信号传递和随之而来的肾上腺切片中的嗜铬细胞之间的胞质Ca2 +增加：儿茶酚胺释放中的作用。
7. Agonist-dependent patterns of cytosolic Ca2+ changes in single bovine adrenal chromaffin cells: relationship to catecholamine release. [O] . Stauderman, K A, Murawsky, M M, Pruss, R M 1990

机译：单个牛肾上腺嗜铬细胞胞质钙离子变化的激动剂依赖性模式：与儿茶酚胺释放的关系。

Correlation of Real-Time Catecholamine Release and Cytosolic CA2+ at SingleBovine Chromaffin Cells

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