首页> 美国政府科技报告 >Sigma Receptor-Mediated Neuroprotection Against Glutamate Toxicity in Primary RatNeuronal Cultures

【24h】

Sigma Receptor-Mediated Neuroprotection Against Glutamate Toxicity in Primary RatNeuronal Cultures

机译：西格玛受体介导的神经保护作用对抗大鼠大脑神经细胞中的谷氨酸毒性

获取原文

页面导航

摘要
著录项
相似文献
相关主题

摘要

The role of the putative a receptor in mediating neuroprotection againstglutamate-induced neuronal injury was examined in mature cultured rat cortical neurons. With the exception of the selective a1 ligand (+ )-3-PPP, all of the a ligands tested were neuroprotective, preventing glutamate-induced morphological changes and increases in LDH release. Their rank order of neuroprotective potency

著录项

作者
DeCoster, M. A.; Klette, K. L.; Knight, E. S.; Tortella, F. C.;
展开▼
作者单位

展开▼
年度 1995
页码
总页数 11
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Toxicity; Wounds and injuries; Central nervous system; Damage; Models; Glutamicacid; In vitro analysis; Correlation; Ligands; Protection; Nerve cells; Salts; In vivo analysis; Rank order statistics; Chemotherapeutic agents; Cyclazocine; Reprints;

机译：毒性;伤口和损伤;中枢神经系统;损伤;模型;谷氨酸;体外分析;相关性;配体;保护;神经细胞;盐;体内分析;秩序统计;化疗药物; Cyclazocine;重印;

相似文献

外文文献
中文文献
专利

1. Stereoselective neuroprotection by novel 2,3-benzodiazepine non-competitive AMPA antagonist against non-NMDA receptor-mediated excitotoxicity in primary rat hippocampal cultures. [J] . May PC, Robison PM, Fuson KS Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 1999,第3期

机译：新型的2,3-苯并二氮杂non非竞争性AMPA拮抗剂对非NMDA受体介导的兴奋性中枢神经毒性的立体选择性神经保护作用。
2. Analysis of Neuroprotection by Taurine and Taurine Combinations in Primary Neuronal Cultures and in Neuronal Cell Lines Exposed to Glutamate Excitotoxicity and to Hypoxia/Re-oxygenation [J] . Prentice Howard, Pan Chunliu, Gharibani Payam M., Advances in Experimental Medicine and Biology . 2017,第Pta1期

机译：原发性神经元培养中牛磺酸和牛磺酸组合的神经保护分析及暴露于谷氨酸兴奋毒性的神经元细胞系和缺氧/重氧化
3. Analysis of Neuroprotection by Taurine and Taurine Combinations in Primary Neuronal Cultures and in Neuronal Cell Lines Exposed to Glutamate Excitotoxicity and to Hypoxia/Re-oxygenation [J] . Prentice Howard, Pan Chunliu, Gharibani Payam M., Advances in Experimental Medicine and Biology . 2017,第Pta2期

机译：原发性神经元培养中牛磺酸和牛磺酸组合的神经保护分析及暴露于谷氨酸兴奋毒性的神经元细胞系和缺氧/重氧化
4. Single Neuron Imaging Reveals Metabotropic Glutamate Receptor-Mediated Bursting and Delay in Calcium Oscillation in Hippocampal Neurons [C] . Ranjana Singh, Abha Saxena, Lopamudra Giri Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2019

机译：单神经元成像显示海马神经元代谢型谷氨酸受体介导的爆发和钙振荡的延迟。
5. Postmortem interval and anesthetic neuroprotection in regenerating cortical neuron cultures used as a model for TNF neuroprotection from beta-amyloid toxicity. [D] . Viel, John Jay. 2000

机译：再生皮层神经元培养物中的死后间隔和麻醉神经保护被用作TNF神经保护免受β-淀粉样蛋白毒性的模型。
6. Glutamate Receptor-Mediated Neurotoxicity in a Model of Ethanol Dependence and Withdrawal in Rat Organotypic Hippocampal Slice Cultures [O] . Elisabetta Gerace, Elisa Landucci, Daniele Bani, 2018

机译：谷氨酸受体介导的乙醇依赖和戒断大鼠器官型海马切片培养物中的神经毒性。
7. Neuroprotection by chotosan, a Kampo formula, against glutamate excitotoxicity involves the inhibition of GluN2B-, but not GluN2A-containing NMDA receptor-mediated responses in primary cultured cortical neurons [O] . Sachie Sasaki-Hamada, Azusa Suzuki, Emi Sanai, 2017

机译：通过chotosan（一种汉方公式）对谷氨酸兴奋毒性的神经保护作用涉及GluN2B-的抑制，而不是原代培养皮层神经元中含GluN2a的NmDa受体介导的反应。
8. Acute and Chronic Effects of Estrogenic Compounds on glutamate-StimulatedPhosphatidylinositol Metabolism in Primary Neuronal Cultures [R] . Yourick, D. L., DeCoster, M. A. 1996

机译：雌激素化合物对原代神经元培养物中谷氨酸刺激的磷脂酰肌醇代谢的急性和慢性影响

Sigma Receptor-Mediated Neuroprotection Against Glutamate Toxicity in Primary RatNeuronal Cultures

摘要

著录项

相似文献

相关主题

期刊订阅