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Expression of Fos, Jun and AP-1 DNA Binding Activity in Rat Supraoptic Nucleus Neurons Following Acute Versus Repeated Osmotic Stimulation.

机译：急性反复渗透刺激后大鼠视上核神经元Fos，Jun和ap-1 DNa结合活性的表达。

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FOB and Jun are protein products of their respective proto-oncogenes, c-fos and c-jun. Nuclear concentrations of both proteins rapidly, but transiently, rise after thepresentation of a variety of stimuli under in vitro and in vivo conditions. Fos and Jun can form heterodimeric proteins that act as transcription factors to regulate late response genes.Previous work has demonstrated that hypertonic saline injection results in Fos expression in supraoptic nucleus (SON) neurons that mediate body water homeostasis. Since Fos is thought to act mostly in conjunction with Jun, I first developed a double-label fluorescence immunocytochemical procedure that permits simultaneous visualization of neurons expressing Fos and Jun. After hypertonic saline administration, the immunostaining of c-Fos and c-Jun was coexistent in the majority of rnagnocellular neurons of SON.

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Wang, K.;
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年度 1995
页码 1-176
总页数 176
原文格式 PDF
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Proteins; Genes; Hybridization; Saline solution; Deoxyribonucleic acids; Stimulation (physiology); Gene expression; Nervous system; Transcription (genetics); Hypothalamus; Rats; Cytochemistry; Immunochemistry; Ribonucleic acids; Plasmids; Son (supraoptic nucleus); Son neurons; Dna binding; Fos; Jun; Ap-1; Dna (deoxyribonucleic acids); Osmotic stimulation; Oncogenes; C-fos; C-jun; Hypothalamo-neurohypophysial system; Fluid imbalance; Immunocytochemistry; Rna (ribonucleic acids); Mrna (micro rna); Northern blotting analysis;

机译：蛋白质;基因;杂交;盐水溶液;脱氧核糖核酸;刺激（生理学）;基因表达;神经系统;转录（遗传学）;下丘脑;大鼠;细胞化学;免疫化学;核糖核酸;质粒;儿子（视上核）;儿子神经元; Dna结合; Fos; Jun; ap-1; Dna（脱氧核糖核酸）;渗透刺激;癌基因; C-fos; C-jun;下丘脑 - 神经垂体系统;液体失衡;免疫细胞化学; Rna（核糖核酸）; mrna（微rna ）; Northern印迹分析;

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专利

1. Effect of intra-ischemic hypothermia on the expression of c-Fos and c-Jun, and DNA binding activity of AP-1 after focal cerebral ischemia in rat brain. [J] . Akaji K, Suga S, Fujino T, Brain research . 2003,第1a2期

机译：局灶性脑低温对大鼠局灶性脑缺血后c-Fos和c-Jun表达及AP-1 DNA结合活性的影响。
2. Time course of Fos and Fras expression in the hypothalamic supraoptic neurons during chronic osmotic stimulation. [J] . Miyata S, Tsujioka H, Itoh M, Brain research. Molecular brain research . 2001,第1期

机译：慢性渗透刺激下丘脑上视神经元中Fos和Fras表达的时程。
3. Acute hyperosmotic stimulus-induced Fos expression in neurons depends on activation of astrocytes in the supraoptic nucleus of rats. [J] . Yuan H, Gao B, Duan L, Journal of Neuroscience Research . 2010,第6期

机译：急性高渗刺激在神经元中诱导的Fos表达取决于大鼠视上核中星形胶质细胞的激活。
4. BINDING AND PROTECTION OF DNA BY A NOVEL PEPTIDE DERIVED FROM THE DNA-BINDING REGION OF THE FOS-JUN COMPLEX [C] . Y. Uesugi, S. Ogata, M. Tanihara International symposium on controlled release of bioactive materials;Consumer diversified products conference . 2001

机译：FOS-JUN复合物的DNA结合区衍生的新型肽对DNA的结合和保护
5. Effects of acetaldehyde on C-Jun/AP-1 expression in oral keratinocytes. [D] . Timmons, Sherry Rene. 2001

机译：乙醛对口腔角质形成细胞中C-Jun / AP-1表达的影响。
6. The Comparison of the Effects of Acute and Repeated Morphine Administration on Fast Synaptic Transmission in Magnocellular Neurons of Supraoptic Nucleus Plasma Vasopressin Levels and Urine Volume of Male Rats [O] . Mitra Yousefpour, Nima Naderi, Zahra Mansouri, 2014

机译：急性和重复吗啡给药对雄性大鼠视上核大细胞神经元快速突触传递血浆加压素水平和尿液量影响的比较
7. Transformation by the fos or jun oncogene does not increase AP-1 DNA-binding activity [O] . K L Hawker, A Pintzas, R F Hennigan, 1993

机译：FOS或Jun Oncogene的转型不会增加AP-1 DNA结合活性

Expression of Fos, Jun and AP-1 DNA Binding Activity in Rat Supraoptic Nucleus Neurons Following Acute Versus Repeated Osmotic Stimulation.

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