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首页> 美国政府科技报告 >Yersinia pestis pH 6 Antigen Forms Fimbriae and Is Induced by IntracellularAssociation with Macrophages
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Yersinia pestis pH 6 Antigen Forms Fimbriae and Is Induced by IntracellularAssociation with Macrophages

机译：鼠疫耶尔森氏菌pH6抗原形成菌毛，并通过与巨噬细胞的细胞内协同诱导

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Ability to express pH 6 antigen (Ag) is necessary for full virulence of Yersiniapestis; however, the function of the Ag in pathogenesis remains unclear. We determined the nucleotide sequence of a 4,232 basepair region of Y. pestis DNA which encoded the pH 6 Ag structural gene (psaA) and accessory loci necessary for Ag synthesis. Protein sequences encoded by the Y. pestis DNA were similar to accessory proteins which function in the biosynthesis of Escherichia coli fimbriae Pap, K88 K99 and CS3 as well as the molecular chaperone for the Y. pestis capsule protein. Electron microscopy and immunogold labeling studies revealed that pH 6 Ag expressing E. coli or Yersinia produced flexible fibrillar organelles composed of individual linear strands, multiple strand bundles or wiry aggregates of PsaA. Y. pestis associated with the murine macrophage-like cell line, RAW264.7, expressed pH 6 Ag in an intracellular acidification dependent manner. With a earlier study showing that a Y. pestis pasA mutant was reduced in virulence, these results demonstrate that the expression of fimbriae which are induced in host macrophages are involved in plague pathogenesis. Yersinia, Fimbriae, Antigen, Macrophage.

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