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ATP Specifically Bound as a Hapten to a Monoclonal Anti-Phospholipid AntibodyRetains Phosphate Donor Activity

机译：特异性结合的aTp作为单克隆抗磷脂抗体的一部分，可以恢复磷酸盐供体活性

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We have previously reported that each of four monoclonal antibodies to aphospholipid, phosphatidylinositol phosphate (PIP), has a phosphate binding subsite in the antigen binding site that can bind ATP has the ability to donate a phosphate group in the phosphorylation reaction of glucose to glucose-6-phosphate catalyzed by hexokinase. The phosphorylation reaction proceeds efficiently when ATP is provided as free (nonbound) ATP or as antibody-bound ATP. We conclude that an anti-phospholipid antibody can serve as a carrier of a functionally active nucleotide....ATP, Monoclonal, Anti-phospholipid, Antibody, Phosphate donor.

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Wassef, N. M.; Swartz, G. M.; Alving, B. M.; Alving, C. R.;
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年度 1993
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总页数 8
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Monoclonal antibodies; Phospholipids; Adenosine phosphates; Antigens; Glucose; Hexokinase; Phosphorylation; Sites; Liposomes; Enzymes; Donors(Medicine); Reprints;

机译：单克隆抗体;磷脂;腺苷磷酸;抗原;葡萄糖;己糖激酶;磷酸化;位点;脂质体;酶;供体（医学）;重印;

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1. Conformations of the apo-, substrate-bound and phosphate-bound ATP-binding domain of the Cu(II) ATPase CopB illustrate coupling of domain movement to the catalytic cycle [J] . Jayakanthan S., Roberts S.A., Weichsel A., Bioscience Reports . 2012,第5期

机译：Cu（II）ATPase CopB的载脂蛋白，底物结合和磷酸盐结合的ATP结合结构域的构象说明了域运动与催化循环的耦合
2. Conformations of the apo-, substrate-bound and phosphate-bound ATP-binding domain of the Cu(II) ATPase CopB illustrate coupling of domain movement to the catalytic cycle [J] . Andrzej Weichsel, José?M. Argüello, Megan?M. McEvoy, Bioscience Reports . 2012,第5期

机译：Cu（II）ATPase CopB的载脂蛋白，底物结合和磷酸盐结合的ATP结合域的构象说明了域运动与催化循环的耦合
3. Beef‐heart mitochondrial F1‐ATPase can use endogenous bound phosphate to synthesize ATP in dimethyl sulfoxide [J] . Beharry Seelochan, Bragg Philip D. FEBS Letters . 1991,第2期

机译：牛肉心线粒体F1-ATPase可以使用内源结合磷酸盐合成二甲亚砜中的ATP
4. Use of ultrasound to control ion transport via changes in membrane bound ATPase activity [C] . Flanders, C., Fisher, . 1998

机译：使用超声波通过改变膜结合的ATPase活性来控制离子运输
5. The mechanism of ATP hydrolysis in nitrogenase using tetralabeled phosphate and ATP [D] . Krause, Stephan Oswald 1999

机译：四标记磷酸盐和ATP在固氮酶中ATP水解的机理
6. Conformations of the apo- substrate-bound and phosphate-bound ATP-binding domain of the Cu(II) ATPase CopB illustrate coupling of domain movement to the catalytic cycle [O] . Samuel Jayakanthan, Sue A. Roberts, Andrzej Weichsel, 2012

机译：Cu（II）ATPase CopB的载脂蛋白底物结合和磷酸盐结合的ATP结合域的构象说明了域运动与催化循环的耦合
7. Conformations of the apo-, substrate-bound and phosphate-bound ATP-binding domain of the Cu(II) ATPase CopB illustrate coupling of domain movement to the catalytic cycle [O] . Samuel Jayakanthan, Sue A. Roberts, Andrzej Weichsel, 2012

机译：Cu（II）ATP酶COPB的APO-，底物结合和磷酸盐结合ATP结合结构域的构象示出了域运动与催化循环的偶联
8. Crystallization of the Fab Fragment of a Monoclonal Anti-Spin-Label Antibody with and without Bound Hapten. [R] . Leahy, D. J., Hynes, T., Fox, R. O., 1988

机译：具有和不具有结合半抗原的单克隆抗自旋标记抗体的Fab片段的结晶。

ATP Specifically Bound as a Hapten to a Monoclonal Anti-Phospholipid AntibodyRetains Phosphate Donor Activity

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