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首页> 美国政府科技报告 >Replication and Tissue Tropisms of Crimean-Congo Hemorrhagic Fever Virus inExperimentally Infected Adult Hyalomma truncatum (Acari: Ixodidae)
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Replication and Tissue Tropisms of Crimean-Congo Hemorrhagic Fever Virus inExperimentally Infected Adult Hyalomma truncatum (Acari: Ixodidae)

机译：克里米亚 - 刚果出血热病毒在实验感染的成年人Hyalomma truncatum（acari：Ixodidae）中的复制和组织趋向

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Adult Hyalomma truncatum Koch ticks were inoculated intracoelomically withCrimean-Congo hemorrhagic fever (CCHF) virus to examine tissue tropisms of this virus in ticks. Virus was recovered from all 185 ticks examined between 2 and 42 d after inoculation with CCHF virus. Titers or virus recovered from unfed male and female ticks were essentially the same (means, l02.4 and 102.5 plaque-forming units PFU per tick, respectively). Infection rates and titers recovered per gland for both salivary glands and reproductive tissues (ovaries and testes) were positively associated with blood feeding; average titers were 10-fold greater in organs from fed compared with those from unfed individuals. In contrast, neither the tick's sex nor feeding status (unfed or engorged) affected the titer of virus recovered from hemolymph (mean, 101.6 PFU/microliters). Although virus was recovered from Malpighian tubules, midgut, muscle, and nervous tissues from nearly all of the ticks tested, viral titers were consistently low. The increase in viral titer associated with blood feeding by ticks appeared to be due primarily to proliferation of tissue (e.g., salivary gland and reproductive tissues), rather than to increased replication in tissue already present.... Insecta, Hyalomma truncatum, Crimean-Congo hemorrhagic fever virus, Replication.

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