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Feasibility of a Subunit Vaccine for Hepatitis A Virus: Studies on thePathogenesis of Hepatitis A and Feasibility Studies on a Hepatitis A Vaccine

机译：甲型肝炎病毒亚单位疫苗的可行性：甲型肝炎疫苗的发病机制及甲型肝炎疫苗可行性研究

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摘要

The overall goals of this contract are to explore the feasibility of thedevelopment of a subunit vaccine for hepatitis A virus (HAV). We have produced HAV structural proteins by recombinant DNA technology and characterized them as antigens for the induction of protective immunity. We have analyzed the replication strategies of HAV which contribute to its distinguishing growth properties and we have identified the HAV protein 3C as a viral protease. We have evaluated the human immune response to HAV infection. Hepatitis A virus, Subunit vaccine, RA I, Typhus, Virus, Vaccines, Biotechnology.

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作者
Ehrenfeld, E.;
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年度 1992
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总页数 25
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Vaccines; Pathogenesis; Hepatitis viruses; Feasibility studies; Antigens; Biotechnology; Contracts; Humans; Immunity; Peptide hydrolases; Proteins; Response(Biology); Strategy; Typhus; Deoxyribonucleic acids; Infectious diseases; Strains(Biology); Antibod;

机译：疫苗;发病机制;肝炎病毒;可行性研究;抗原;生物技术;合同;人类;免疫;肽水解酶;蛋白质;反应（生物学）;策略;斑疹伤寒;脱氧核糖核酸;传染病;菌株（生物学）;抗体;

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1. Assessing the feasibility of hepatitis C virus vaccine trials: Results from the Hepatitis C Incidence and Transmission Study-community (HITS-c) vaccine preparedness study [J] . White Bethany, Madden Annie, Prins Maria, Vaccine . 2014,第42期

机译：评估丙型肝炎病毒疫苗试验的可行性：丙型肝炎发病率和传播研究-社区（HITS-c）疫苗准备研究的结果
2. Assessing the feasibility of hepatitis C virus vaccine trials: Results from the Hepatitis C Incidence and Transmission Study-community (HITS-c) vaccine preparedness study [J] . White Bethany, Madden Annie, Prins Maria, Vaccine . 2014,第42期

机译：评估丙型肝炎病毒疫苗试验的可行性：丙型肝炎发病率和传播研究-社区（HITS-c）疫苗准备研究的结果
3. Prevalence of hepatitis B, tetanus, hepatitis A, human immunodeficiency virus and feasibility of vaccine delivery among injecting drug users in Bangkok, Thailand, 2003-2005. [J] . Sunthornchart S, Linkins RW, Natephisarnwanish V, Addiction . 2008,第10期

机译：泰国曼谷，2003-2005年，乙型肝炎，破伤风，甲型肝炎，人类免疫缺陷病毒的流行以及注射吸毒者中疫苗接种的可行性。
4. DEVELOPMENT AND CHARACTERIZATION OF A MURINE HEPATOMA MODEL EXPRESSING HEPATITIS C VIRUS (HCV) NON-STRUCTURAL ANTIGENS FOR EVALUATING HCV VACCINES [C] . Kamran Haq, Kevin G. Young, Susanne MacLean, Conference on vaccine technology VI . 2018

机译：表达HCV非结构抗原的表达HCV非结构抗原的小鼠肝炎模型的建立和鉴定
5. Chimeric orthohepadnavirus core particles for oral delivery of vaccines: Part I. Transformation of tobacco plants with a gene encoding a c-terminus truncated hepatitis B virus core protein. Part II. Construction of a woodchuck hepatitis virus core protein-based universal epitope carrier and test expression in Escherichia coli. [D] . Callaghan, Maximilian W. 2001

机译：用于口服递送疫苗的嵌合正丙肝病毒核心颗粒：第一部分。用编码c末端截短的乙型肝炎病毒核心蛋白的基因转化烟草植物。第二部分基于土拨鼠肝炎病毒核心蛋白的通用表位载体的构建和大肠杆菌中的表达测试。
6. Assessing the feasibility of hepatitis C virus vaccine trials: Results from the Hepatitis C Incidence and Transmission Study- community (HITS-c) vaccine preparedness study [O] . Bethany White, Annie Madden, Maria Prins, -1

机译：评估丙型肝炎病毒疫苗试验的可行性：丙型肝炎发病率和传播研究社区（HITS-c）疫苗准备研究的结果
7. Assessing the feasibility of hepatitis C virus vaccine trials: results from the Hepatitis C Incidence and Transmission Study-community (HITS-c) vaccine preparedness study [O] . White, Bethany, Madden, Annie, Prins, Maria, 2014

机译：评估丙型肝炎病毒疫苗试验的可行性：丙型肝炎发病率和传播研究社区（HITS-c）疫苗准备研究的结果
8. Studies on the Pathogenesis of Hepatitis A and Feasibility Studies on a Hepatitis A Vaccine [R] . Ehrenfeld, E., Richards, O. R., Summers, D. F. 1988

机译：甲型肝炎疫苗发病机制及甲型肝炎疫苗可行性研究

Feasibility of a Subunit Vaccine for Hepatitis A Virus: Studies on thePathogenesis of Hepatitis A and Feasibility Studies on a Hepatitis A Vaccine

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