Combinatorial Therapy Approaches for NF2-Deficient Meningiomas.

机译：NF2缺陷性脑膜瘤的组合治疗方法。

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The aim of our research is to find novel targeted therapy for NF2 patients to provide a new therapeutic option for meningiomas that includes the standard of care radiotherapy. We have successfully selected four small molecule compounds that preferentially inhibit NF2 mutant meningioma cells in vitro. These are FDA approved drugs that are safe for human use. We validated these drugs by using human cell lines and tested their ability to synergize with radiation. We have optimized the use of a CT-guided conformal radiation that can be tested in a meningioma mouse model. The findings from this research project will be valuable for future clinical trials, for testing combinatorial approaches to treat meningioma patients.

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作者
Baia, G. S.;
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年度 2013
页码 1-55
总页数 55
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Meninges; Therapy; Cells(Biology); Clinical trials; Combinatorial analysis; Drugs; Neoplasms; Patients; Radiation; Safety; User needs; Meningioma; Nf2(Neurofibromatosis type 2); Hdac inhibitors; Nf2 tumor suppressor gene;

机译：脑膜;治疗;细胞（生物学）;临床试验;组合分析;药物;肿瘤;患者;放射;安全性;用户需要;脑膜瘤; Nf2（神经纤维瘤病2型）; Hdac抑制剂; Nf2肿瘤抑制基因;

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8. Combinatorial Therapy Approaches for NF2-Deficient Meningiomas. [R] . Baia, G. S. 2012

机译：NF2缺陷性脑膜瘤的组合治疗方法。

Combinatorial Therapy Approaches for NF2-Deficient Meningiomas.

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