• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国政府科技报告 >Purification and Radiolabeling of Clostridium botulinum Type F Neurotoxin
【24h】

Purification and Radiolabeling of Clostridium botulinum Type F Neurotoxin

机译：肉毒梭菌F型神经毒素的纯化和放射性标记

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Botulism, a frequently fatal disease affecting both humans and animals, is causedby any one of seven antigenically different neurotoxins (types A-G) produced by various strains of the bacterium Clostridium botulinum. Botulinum F neurotoxin, a typical representative of this family of potent neuroparalytic agents, is a protein of molecular mass approximately 155 kDa consisting of heavy (ca. 105 kDa) and light (ca. 55 kDa) subunits linked by a disulfide bridge. The primary site of action of all the botulinum neurotoxins is the neuromuscular junction where, following a binding step in which toxin molecules interact with acceptor sites on the presynaptic nerve surface, they enter the nerve ending and block the calcium-dependent release of neurotransmitter. Not all the botulinum neurotoxins appear to recognize the same type of acceptor molecule on the presynaptic nerve surface and once inside the nerve ending not all the toxin types appear to block the transmitter release process by the same mechanism.

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号