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Vaccines Against Coxiellosis and Q Fever. Development of a Chloroform: MethanolResidue Subunit of Phase I Coxiella burnetii for the Immunization of Animals

机译：针对柯克斯病和Q热的疫苗。开发氯仿：甲醇补体亚基第一期Coxiella burnetii用于动物免疫

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In a recent review about Q fever in animals, Dr. G. H. Lang resurrected the term'Coxiellosis' which means 'infection by Coxiella Burnetti.' In this sense, infection is not synonymous with overt disease. In our paper, infection will refer to the multiplication of the bacterium in the phagolysosome of nucleated cells. Q fever is defined as the state of infection that produced clinical features of the disease in immunocompetent hosts. We are in agreement with Dr. Lang that 'Coxiellosis is more meaningful than Q fever for the Coxiella infection in animals because it denotes an etiologic concept.' Coxiellosis in animals is rarely recognized by veterinarians as a clinically significant disease. The infection, which is predominantly in apparent in animals, represents a major reservior for the aerosol dissemination of C. burnetti to humans.

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Williams, J. C.; Peacock, M. G.; Waag, D. M.; Kent, G.; England, M. J.;
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年度 1992
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总页数 24
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Q fever; Vaccines; Bacterial diseases; Coxiella burnetii; Immunization; Cells(Biology); Guinea pigs; In vitro analysis; Lipopolysaccharides; Response(Biology); Antibodies; Antigens; Membranes(Biology); Reprints;

机译：Q热;疫苗;细菌性疾病; Coxiella burnetii;免疫;细胞（生物学）;豚鼠;体外分析;脂多糖;反应（生物学）;抗体;抗原;膜（生物学）;重印;

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专利

1. Low-Dose Priming before Vaccination with the Phase I Chloroform-Methanol Residue Vaccine against Q Fever Enhances Humoral and Cellular Immune Responses to Coxiella burnetii [J] . David M. Waag, Marilyn J. England, Christopher R. Bolt, Clinical and vaccine immunology: CVI . 2008,第10期

机译：在针对Q发热的I相氯仿-甲醇残留疫苗接种前进行小剂量启动可增强对Burnetii柯氏菌的体液和细胞免疫反应
2. Characterization of a phase I Coxiella burnetii chloroform-methanol residue vaccine that induces active immunity against Q fever in C57BL/10 ScN mice. [J] . J C Williams, T A Damrow, D M Waag, Infection and immunity . 1986,第3期

机译：I型Coxiella Burnetii氯仿 - 甲醇残留疫苗的表征在C57BL / 10 SCN小鼠中诱导Q发热的积极免疫。
3. An epidemiological investigation of Q fever (Coxiellosis) in human, dogs and cats in the Tokyo metropolitan area, and studies on the development of an effective detection method for Coxiella burnetii in foodstuffs [J] . Kenji SADAMASU 日本兽医畜産大学研究報告 . 2006,第55期

机译：东京都会区人，狗和猫的Q发热（Coxiellosis）流行病学调查，以及对食品中伯氏杆菌的有效检测方法的开发研究
4. DEVELOPMENT OF A VACCINE BASED ON RECOMBINANT SUBUNIT PROTEINS TO PROTECT HUMANS AND ANIMALS AGAINST FILOVIRUS DISEASE [C] . Axel T. Lehrer, Michael M. Lieberman Vaccine technology VI . 2016

机译：基于重组亚单位蛋白的疫苗的开发以保护人类和动物抵抗黄萎病
5. Coxiella burnetii: Intranasal Immunizations and Axenic Media Adaptations [D] . Brewer, Melissa N. 2020

机译：Coxiella Burnetii：鼻内免疫和轴静脉介质适应
6. Low-Dose Priming before Vaccination with the Phase I Chloroform-Methanol Residue Vaccine against Q Fever Enhances Humoral and Cellular Immune Responses to Coxiella burnetii [O] . David M. Waag, Marilyn J. England, Christopher R. Bolt, 2008

机译：在针对I型热的I期氯仿-甲醇残留疫苗接种前进行小剂量启动可增强对Burnetii柯氏菌的体液和细胞免疫反应
7. Low-Dose Priming before Vaccination with the Phase I Chloroform-Methanol Residue Vaccine against Q Fever Enhances Humoral and Cellular Immune Responses to Coxiella burnetii▿ [O] . Waag, David M., England, Marilyn J., Bolt, Christopher R., 2008

机译：在针对Q发热的I相氯仿-甲醇残留疫苗接种前进行小剂量启动，可增强对Burnetii的体液和细胞免疫反应
8. Low-Dose Priming Before Vaccination with the Phase I Chloroform- Methanol Residue Vaccine Against Q Fever Enhances Humoral and Cellular Immune Responses to Coxiella Burnetii [R] . Waag, D. M., England, M. J., Bolt, C. R., 2008

机译：用I期氯仿 - 甲醇残留疫苗接种针对Q热的疫苗接种前的低剂量引发增强了对Coxiella Burnetii的体液和细胞免疫应答

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Vaccines Against Coxiellosis and Q Fever. Development of a Chloroform: MethanolResidue Subunit of Phase I Coxiella burnetii for the Immunization of Animals

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