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首页> 美国政府科技报告 >Novel Approaches for Targeting Antiviral Agents in the Treatment of Arena-, Bunya-, Flavi-, and Retroviral Infections
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Novel Approaches for Targeting Antiviral Agents in the Treatment of Arena-, Bunya-, Flavi-, and Retroviral Infections

机译：靶向抗病毒药物治疗竞技场，布尼亚，弗拉维和逆转录病毒感染的新方法

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The first year of this contract was devoted to the conjugation of selectedantivirals (ribavirin and PMEA) and immunomodulators (MDP) to neoglycoprotein carriers (poly-L-lysine or BSA). Our in vivo virus challenge studies suggest that MDP-BSA and poly-L-lysine conjugates were more effective than free MDP in enhancing resistance to HSV-1 hepatitis and pneumonitis. Moreover, conjugated MDP was more effective in enhancing RES function than was free drug. In addition, conjugated PMEA was more effective than free drug in reducing virus titers in lungs of infected mice. Squirrel monkeys were shown to be useful in the evaluation of an orally administered immunomodulating agent, CL 246738, as evidenced by the induction of serum interferon. Thus this primate model was selected for the preclinical evaluation of promising new drugs.

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