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Gastric Injury and Invasion of Parietal Cells by Spiral Bacteria in RhesusMonkeys. Are Gastritis and Hyperchlorhydria Infectious Diseases

机译:猕猴螺旋菌对胃壁细胞的胃损伤及侵袭。是胃炎和高氯酸钾传染病

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The cause of gastritis and of gastric ulcer is unknown, but gastric acidsecretion is believed to play an important role in the pathogenesis of these conditions. Epidemiological data have suggested that histological gastritis may be caused by Helicobacter pylori (previously named Campylobacter pylori) and that the increased prevalence of this disease in older individuals is associated with a greater frequency of infection with this organism (1). Experimental transmission of H. pylori to two healthy volunteers has resulted in acute clinical illnesses characterized by epigastric pain, histological gastritis, and hypochlorhydria (2,3). Both subjects were treated with antimicrobial agents, and one of them recovered rapidly and completely. However, the other subject developed chronic gastritis which was only partly healed 103 days after ingestion of the bacteria. No duodenal ulcer developed in either subject.

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