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Roles of Interleukin-1 and Tumor Necrosis Factor in Lipopolysaccharide-InducedHypoglycemia

机译：白细胞介素-1和肿瘤坏死因子在脂多糖诱导的低血糖症中的作用

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In this study, hypoglycemia induced by injection of lipopolysaccharide (LPS) orthe recombinant cytokine interleukin-1Alpha or tumor necrosis factor alpha (administered alone or in combination) was compared. LPS-induced hypoglycemia was reversed significantly by recombinant interleukin-1 receptor antagonist. Among the varied responses elicited by administration of lipopolysaccharide (LPS) in vivo is a modulation of glucose metabolism, which in mice results in dose-dependent hypoglycemia (reviewed in references 18, 21,22, and 30). LPS (3,4,7,8,15,21,22,25). Thus, is has been hypothesized that IL-1 and TNF act as probable intermediates in LPS-induced hypoglycemia. However, we recently demonstrated that administration of a rabbit polyclonal immunoglobulin prepared against recombinant murine TNF to mice failed to block LPS-induced hypoglycemia, under conditions in which a highly significant inhibition of serum colony-stimulating factor (CSF) activity was observed.

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作者
Vogel, S. N.; Henricson, B. E.; Neta, R.;
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年度 1991
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总页数 6
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Hypoglycemia; Lipopolysaccharides; Glucose; In vivo analysis; Inhibition; Metabolism; Mice; Modulation; Necrosis; Neoplasms; Reprints;

机译：低血糖症;脂多糖;葡萄糖;体内分析;抑制;代谢;小鼠;调节;坏死;肿瘤;重印;

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2. Evidence against a role for polymorphisms at tumor necrosis factor, interleukin-1 and interleukin-1 receptor antagonist gene loci in the regulation of disease severity in acute pancreatitis. [J] . Powell JJ, Fearon KC, Siriwardena AK, Surgery . 2001,第5期

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4. Tumor Necrosis Factor-α (TNF-α) might play a role in the postprandial metabolism regulation in Duroc×Landrace×Large White growing barrows [C] . H.J.Xu, W.Du, Y.J.LI, Progress in functional amino acids and carbohydrates for animal production . 2009

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机译：白细胞介素-6，白细胞介素-1和肿瘤坏死因子在促肾上腺皮质激素对体内细菌脂多糖反应中的协同作用

Roles of Interleukin-1 and Tumor Necrosis Factor in Lipopolysaccharide-InducedHypoglycemia

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