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首页> 美国政府科技报告 >Infection of Inbred Rat Strains with Rift Valley Fever Virus: Development of aCongenic Resistant Strain and Observations on Age-Dependence of Resistance
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Infection of Inbred Rat Strains with Rift Valley Fever Virus: Development of aCongenic Resistant Strain and Observations on Age-Dependence of Resistance

机译：裂谷热病毒近交系大肠杆菌的感染：抗性品系的发育及抗性年龄依赖性的观察

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Resistance of adult rats to hepatic disease induced by the virulent ZH501 strainof Rift Valley fever virus (RVFV) has been shown to be under the control of a Mendelian dominant gene or closely linked gene complex. Adult rat strains such as Wistar-Furth (WF) that are highly susceptible to Egyptian strains (e.g., ZH501) of RVFV generally survive infection with sub-Sahara strains (e.g., SA75), even though both Egyptian and sub-Saharan RVFV strains have similar pathogenicity for sheep and rodents in the laboratory, and there are no convincing data to suggest a different lethality for humans or domestic animals during natural transmission.

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