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首页> 美国政府科技报告 >Novel Fold and Putative Receptor Binding Site of Granulocyte-Macrophage Colony-Stimulating Factor
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Novel Fold and Putative Receptor Binding Site of Granulocyte-Macrophage Colony-Stimulating Factor

机译：新型粒细胞 - 巨噬细胞集落刺激因子的折叠和推定受体结合位点

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Granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulates thedevelopment of and the cytotoxic activity of white blood cells. Recombinant human GM-CSF has proven useful in the treatment of blood disorders. The structure of GM-CSF, which was determined at 2.4 angstrom resolution by x-ray crystallography, has a novel fold combining a two-stranded antiparallel beta sheet with an open bundle of four alpha helices. Residues implicated in receptor recognition, which are distant in the primary sequence, are on adjacent alpha helices in the folded protein. A working model for the receptor binding site is presented. Natural GM-CSF is a 127-amino acid residue trace glycoprotein (1, 2) that triggers the development of both granulocyte and macrophage colonies from hematopoietic progenitor cells (3). The availability of recombinant GM-CSF (2, 4, 5) has allowed a much fuller characterization of its activities, and it is now clear that GM-CSF stimulates a wide variety of hematopoietic and non-hematopoietic cell types.

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