Modular Approach to Protein Design.

机译：蛋白质设计的模块化方法。

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We have taken a modular approach to study peptide interactions with proteins as a model for protein-protein interactions. Two basic approaches were applied to this problem, and peptides were designed to bind either a specific sequence of double stranded DNA or the PP56lck tyrosine protein kinase. This protein kinase likely is the cytoplasmic effector of CD4, a transmembrane receptor whose aviation in vivo is associated with an increase in cytoplasmic free calcium. Peptides have been synthesized which bind to each of these macromolecules with KDs near 2mM. In addition to binding pp56lck tightly, one peptide has been found to stimulate the activity of this enzyme up to 20-fold. We have shown that ionic interactions are important for this activation, and that these peptides alter the substrate specificity of this enzyme. Due to our greater success with the protein kinase project, we have recently been concentrating our efforts on this project.

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作者
Bramson, H. N.;
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年度 1991
页码 1-6
总页数 6
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Activation; Aeronautics; Calcium; Cytoplasm; Deoxyribonucleic acids; Enzymes; In vivo analysis; Interactions; Macromolecules; Modular construction; Peptides; Proteins; Sequences; Protein structure; Protein engineering; Protein-tyrosine kinase; Enzyme activation;

机译：激活;航空;钙;细胞质;脱氧核糖核酸;酶;体内分析;相互作用;大分子;模块构建;肽;蛋白质;序列;蛋白质结构;蛋白质工程;蛋白质酪氨酸激酶;酶激活;

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6. A self-consistent knowledge-based approach to protein design. [O] . A Rossi, C Micheletti, F Seno, 2001

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7. Helix construction using a-aminoisobutyryl residues in a modular approach to synthetic protein design. Conformational properties of an apolar decapeptide in two different crystal forms and in solution [O] . Karle Isabella L, Flippen-Anderson JL, Uma K, 1990

机译：在合成蛋白质设计的模块化方法中，使用α-氨基异丁酰基残基构建螺旋结构。两种不同晶型和溶液中非极性十肽的构象性质

Modular Approach to Protein Design.

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