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Isolation of a Toxin from Venom of Wagler's Pit Viper Trimeresurus wagleri.

机译：从Wagler的pit蛇毒龙舌兰毒液中分离出一种毒素。

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A lethal toxin was isolated from Trimeresurus wagleri venom by fast protein liquid chromatography (molecular sieve) and Biorex-70 cation exchange. The toxin had an M(r) of approximately 9.5 kD, a pl of 9.6-9.9, did not exhibit subunit behavior in SDS-PAGE profiles and lacked phospholipase A, proteolytic, and hemolytic activity. The toxin had an i.p. LD(50) of 0.072 mg/kg. The lethal activity was found to represent less than 1% of the total venom protein, which was only 62-65% of crude venom. The toxin lacked antigenic identity with a number of representative neurotoxins and myotoxins. The crude venom shared at least one antigen with Crotalus scutulatus venom. This antigen was not Mojave toxin. The toxin appears symptomologically suggestive of a vasoactive peptide or neurotoxin with specific blocking activity upon respiratory innervation. Keywords: Nerve blocking. (sdw)

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作者
Weinstein, S. A.; Bernheimer, A. W.; Smith, L. A.;
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年度 1990
页码 1-23
总页数 23
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Neurotoxins; Toxins and antitoxins; Venoms; Antigens; Cardiovascular agents; Cns depressants; Enzymes; Hemolysis; Isolation; Lethality; Liquid chromatography; Molecular sieves; Nerve blocking; Peptides; Phospholipids; Proteins; Snakes;

机译：神经毒素;毒素和抗毒素;毒液;抗原;心血管药物; Cns抑制剂;酶;溶血;分离;致死率;液相色谱;分子筛;神经阻滞;肽;磷脂;蛋白质;蛇;

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专利

1. STRUCTURE-FUNCTION STUDIES OF WAGLERIN I, A LETHAL PEPTIDE FROM THE VENOM OF WAGLERS PIT VIPER, TRIMERESURUS WAGLERI [J] . Schmidt JJ., Weinstein SA. Toxicon: An International Journal Devoted to the Exchange of Knowledge on the Poisons Derived from Animals, Plants and Microorganisms . 1995,第8期

机译：Waglerin I的结构功能研究，Wagelers Pit VIPer的毒液中的一种肽，Trimeresurus Wagleri
2. Delineating the venom toxin arsenal of Malabar pit viper (Trimeresurus malabaricus) from the Western Ghats of India and evaluating its immunological cross-reactivity and in vitro cytotoxicity [J] . International Journal of Biological Macromolecules: Structure, Function and Interactions . 2020,第期

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3. Toxicity and cross-neutralization of snake venoms from two lesser-known arboreal pit vipers in Southeast Asia: Trimeresurus wiroti and Trimeresurus puniceus [J] . Lee Louisa Pernee, Tan Kae Yi, Tan Choo Hock Toxicon: An International Journal Devoted to the Exchange of Knowledge on the Poisons Derived from Animals, Plants and Microorganisms . 2020,第1期

机译：来自东南亚的两个鲜明的树栖盆毒蛇蛇毒液的毒性和交叉中和：Trimeresurus wiroti和timeresurus punyusus
4. Development of In Vitro Assays for Hematotoxic Activity of the Russell's Viper Daboia siamensis venom [C] . Patchara Sittishevapark, Jirarach Kitana, Suchada Sukrong, International Conference on Biology and Applied Science . 2019

机译：罗素毒品毒蛇毒素苏丹毒素血管毒性活动的体外测定
5. Functional characterization of human glycoprotein Ib (GPIb) in platelets and endothelial cells using viper venom proteins. [D] . Tan, Li. 1998

机译：使用毒蛇毒蛋白在血小板和内皮细胞中人糖蛋白Ib（GPIb）的功能表征。
6. Venomics of Trimeresurus (Popeia) nebularis the Cameron Highlands Pit Viper from Malaysia: Insights into Venom Proteome Toxicity and Neutralization of Antivenom [O] . Choo Hock Tan, Kae Yi Tan, Tzu Shan Ng, 2019

机译：来自马来西亚的金马仑高原P蛇Trimeresurus（Popeia）星云的经济学：对毒液蛋白质组学抗毒液的毒性和中和的见解
7. Venom Composition in a Phenotypically Variable Pit Viper (Trimeresurus insularis) across the Lesser Sunda Archipelago [O] . -1

机译：毒液组成在较小的Sunda群岛上的表型可变坑毒蛇（Timeresurus entularis）中

Isolation of a Toxin from Venom of Wagler's Pit Viper Trimeresurus wagleri.

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