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首页> 美国政府科技报告 >Effects of Poloxamer 188 on Hemodynamics and Survival in a Rabbit Model ofHemorrhagic Shock and Retransfusion
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Effects of Poloxamer 188 on Hemodynamics and Survival in a Rabbit Model ofHemorrhagic Shock and Retransfusion

机译：泊洛沙姆188对失血性休克和再输血兔血流动力学和存活率的影响

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摘要

The effects of an antithrombotic, rheologic agent (Poloxamer 188) were examinedin an acute model of severe hemorrhagic shock in rabbits. Anesthetized rabbits were instrumented for comprehensive hemodynamic monitoring. Blood was withdrawn to reduce the mean arterial pressure to 35 mmHg. The shock state was maintained for 60 minutes, followed by transfusion with autologous warmed shed blood. At the time of transfusion, treated animals received an intravenous bolus of Poloxamer 188 (200 mg), followed by continued infusion of either 50 mg/kg/hr or 200 mg/kg/hr. No demonstrable effects on hemodynamics were observed. However, in animals treated with Poloxamer 188, 13 of 16 animals survived the entire 3 hour monitoring. In contrast, in the group of animals that received the autologous blood but were not treated with Poloxamer 188, only 6 of 16 animals survived. Although additional studies are needed, these results suggest that Poloxamer 188 may favorably affect early mortality when administered in the resuscitation phase of hemorrhagic shock. Keywords: Hemorrhagic shock; Reperfusion injury; Poloxamer 188. (jes)

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