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Complexity of DRw6 DR5 Haplotypes in American Blacks Demonstrated by Serology, Cellular Typing, and Restriction Fragment Length Polymorphism Analysis.

机译：美国黑人DRw6 DR5单倍型的复杂性通过血清学，细胞分型和限制性片段长度多态性分析得到证实。

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The class II region of the human major histocompatibility complex encodes highly polymorphic heterodimeric cell surface glycoproteins (DR, DQ, and DP), which function in the induction of the normal immune response and are responsible in part for allograft rejection and autoimmune disease susceptibility. The polymorphic residues of the class II polypeptides are localized to the amino terminal domains and are clustered into variable regions. In the predicted three-dimensional structure of the class II molecule, the majority of the polymorphic sites reside in the antigen-binding T-cell receptor recognition site suggesting the importance of these residues in controlling antigen recognition and allograft rejection. HLA-D regions that encode molecules carrying DR serologic determinants share general structural features suggesting a common origin. The DRw52 subregion of most of these haplotypes encodes one nonpolymorphic gene (DRA) and three DR genes.

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Lee, K. W.; Hurley, C. K.; Hartzman, R.; Johson, A. H.;
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年度 1990
页码 1-19
总页数 19
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Antigens; Autoimmune diseases; Genes; Glycoproteins; Immunity; Molecules; Recognition; Regions; Rejection; Residues; Response(Biology); Serology; Sites; Structural properties; Structures; Surfaces; Surgical transplantation; Three dimensional; Variables; Reprints; DNA Typing; Black Americans; Restriction fragment length polymorphism; Haplotypes; Histocompatibilty; Minority HLA types; HLA D R;

机译：抗原;自身免疫疾病;基因;糖蛋白;免疫;分子;识别;区域;排斥;残留;反应（生物学）;血清学;位点;结构特性;结构;表面;外科移植;三维;变量;重印; DNa分型;美国黑人;限制性片段长度多态性;单倍型;组织相容性;少数HLa类型; HLa DR;

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2. Evaluation of PCR-Restriction Profile Analysis and IS2404 Restriction Fragment Length Polymorphism and Amplified Fragment Length Polymorphism Fingerprinting for Identification and Typing of Mycobacterium ulcerans andM. marinum [J] . K. Chemlal, G. Huys, P.-A. Fonteyne, Journal of Clinical Microbiology . 2001,第9期

机译：PCR-限制性谱分析和IS2404限制性片段长度多态性和扩增片段长度多态性指纹图谱的鉴定，用于鉴定和分型溃疡分枝杆菌和M。马里纳姆
3. Restriction fragment length polymorphism typing demonstrates substantial diversity among Pneumocystis jirovecii isolates. [J] . Ripamonti C, Orenstein A, Kutty G The Journal of Infectious Diseases . 2009,第10期

机译：限制性片段长度多态性分型显示在杰氏肺孢菌分离株之间存在实质性多样性。
4. Restriction Fragment Length Polymorphism Typing Demonstrates Substantial Diversity among Pneumocystis jirovecii Isolates [J] . Chiara Ripamonti1 Abigail Orenstein1a Geetha Kutty1 Laurence Huang3 Regina Schuhegger4 Andreas Sing4 Giovanna Fantoni1 Chiara Atzori5 Carol Vinton1 Charles Huber2 Patricia S. Conville2 and Joseph A. Kovacs1 Journal of Infectious Diseases . 2009,第10期

机译：限制性片段长度多态性分型表明肺孢菌肺炎双胞胎分离株之间的实质性多样性。
5. Parallel application of Variable-Number Tandem-Repeat Markers typing and IS 1245 Restriction Fragment Length Polymorphism fingerprinting of Finnish Mycobacterium avium from human and porcine origins [C] . Tirkkonen Taneli, Pakarinen Jaakko, Rintala Elina, Congress of the International Pig Veterinary Society . 2008

机译：通过人和猪起源于人和猪起源，可变数量串联重复标记键入和是1245个限制片段长度多态性指纹印刷。来自人和猪起源的芬兰分枝杆菌
6. Role of vitamin D receptor and vitamin D binding protein restriction fragment length polymorphisms in determining dose response to vitamin D: A randomized double blind placebo controlled trial [D] . Sai, Adarsh. 2011

机译：维生素D受体和维生素D结合蛋白限制性片段长度多态性在确定对维生素D的剂量反应中的作用：一项随机双盲安慰剂对照试验
7. HLA-DR2 -DR5 and DRw6 associated Dw subtypes correlate with HLA-DR beta and -DQ beta restriction fragment length polymorphisms. [O] . M P Font, L Gebuhrer, H Betuel, 1986

机译：HLA-DR2-DR5和DRw6相关的Dw亚型与HLA-DR beta和-DQ beta限制性片段长度多态性相关。
8. HLA-DR2, -DR5, and DRw6 associated Dw subtypes correlate with HLA-DR beta and -DQ beta restriction fragment length polymorphisms. [O] . Font, M P, Gebuhrer, L, Betuel, H, 1986

机译：HLA-DR2，-DR5和DRw6相关的Dw亚型与HLA-DR beta和-DQ beta限制性片段长度多态性相关。

Complexity of DRw6 DR5 Haplotypes in American Blacks Demonstrated by Serology, Cellular Typing, and Restriction Fragment Length Polymorphism Analysis.

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