HTLV-I (Human T-Cell Leukemia Virus 1) Seroconversion Study

机译：HTLV-I（人T细胞白血病病毒1）血清转化研究

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A data collection research center has been established on Okinawa for the purpose of studying the risk of HTLV-I transmission to active duty personnel stationed there. Research activities include a period prevalence serosurvey for HTLV-I in 5,267 personnel. Thirty-one of this group were positive by ELISA with confirmatory tests and full laboratory epidemiologic analysis pending. In addition, active duty personnel are being accessioned on arrival to Okinawa for prospective follow-up with repeat serologies and questionnaires throughout their tours to determine rates of seroconversion. Greater than 700 participants are currently accessioned. Preliminary results from the seroprevalence survey suggest that transmission rates may be low. However, final conclusions must await completion of the analysis of the seroprevalence draw and prospective study of personnel during their tours. HTLV-I, the first human retrovirus isolated, has been identified as the etiologic agent for Adult T-Cell Leukemia/Lymphoma (ATLL). In addition, HTLV-I has been linked etiologically to a subset of patients with tropical Spastic Paraparesis (TSP) - a slowly progressive myelopathy. Transmission of the virus occurs parenterally, sexually, and from mother to child (predominantly via breast feeding). Keywords: Epidemiology; Sexually transmitted diseases. (AW)

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作者
Brodine, S. K.;
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年度 1989
页码 p.1-20
总页数 20
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Infectious disease transmission; Viruses; Leukemia; Lymphomas; Data acquisition; Virus diseases; Enzymes; Epidemiology; Etiology; Feeding; Immunoassay; Laboratory tests; Mammary glands; Okinawa; Questionnaires; Rates; Research facilities; Risk;

机译：传染病传播;病毒;白血病;淋巴瘤;数据采集;病毒病;酶;流行病学;病因学;喂养;免疫测定;实验室检测;乳腺;冲绳;调查问卷;比率;研究设施;风险;

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专利

1. Human T-cell leukemia virus type I (HTLV-I) infection and the onset of adult T-cell leukemia (ATL) [J] . Masao Matsuoka Retrovirology . 2005,第2008期

机译：I型人T细胞白血病病毒（HTLV-1）感染和成人T细胞白血病（ATL）的发作
2. Unusual CD4+CD8+ phenotype in a greek patient diagnosed with adult T-cell leukemia positive for human T-cell leukemia virus type I (HTLV-I). [J] . Ciminale V, Hatziyanni M, Felber BK, Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis . 2000,第4期

机译：在希腊患者中，诊断为成人T细胞白血病（人类I细胞白血病病毒I型（HTLV-1））阳性的CD4 + CD8 +表型异常。
3. Human T-cell leukemia virus type-I (HTLV-I) tax is not the only one factor to enhance human immunodeficiency virus type-I (HIV-1) infection in culture-supernatants. [J] . Tempaku A, Maeda Y, Song W, Virus Genes . 2001,第1期

机译：I型人T细胞白血病病毒（HTLV-1）税并不是在培养上清液中增强I型人免疫缺陷病毒（HIV-1）感染的唯一因素。
4. Characterization of cancer specific human monoclonal IgM antibodies produced by hybridomas derived from a patient with adult T-cell leukemia [C] . T. KAWAHARA, A. ICHIKAWA, Y. KATAKURA, Annual Meeting of the Japanese Association for Animal Cell Technology . 2002

机译：杂交瘤产生的癌症特异性人单克隆IgM抗体的表征衍生自成人T细胞白血病患者的杂交瘤
5. Human T-cell lymphotropic virus type I (HTLV-I) activates IL-15Ralpha expression via NF-kappaB and interferon regulatory elements. [D] . Mariner, Jennifer Marie. 2002

机译：I型人T细胞淋巴病毒（HTLV-1）通过NF-κB和干扰素调节元件激活IL-15Ralpha表达。
6. The type I human T-cell leukemia virus (HTLV-I) Rex trans-activator binds directly to the HTLV-I Rex and the type 1 human immunodeficiency virus Rev RNA response elements. [O] . H P Bogerd, G L Huckaby, Y F Ahmed, 1991

机译：I型人T细胞白血病病毒（HTLV-1）Rex反式激活因子直接结合HTLV-1 Rex和1型人免疫缺陷病毒Rev RNA应答元件。
7. The type I human T-cell leukemia virus (HTLV-I) Rex trans-activator binds directly to the HTLV-I Rex and the type 1 human immunodeficiency virus Rev RNA response elements. [O] . Bogerd, H P, Huckaby, G L, Ahmed, Y F, 1991

机译：I型人T细胞白血病病毒（HTLV-1）Rex反式激活因子直接结合HTLV-1 Rex和1型人免疫缺陷病毒Rev RNA应答元件。

HTLV-I (Human T-Cell Leukemia Virus 1) Seroconversion Study

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