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Effects of Hemorrhagic Shock on Antioxidant Enzyme Activities

机译:失血性休克对抗氧化酶活性的影响

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A model of hemorrhagic shock has been developed using rabbits. Rabbits are anesthetized and instrumented for comprehensive hemodynamic monitoring. Blood is withdrawn to obtain a mean arterial pressure of 35 mmHg. Retransfusion with autologous warmed shed blood is performed either 30 or 60 minutes following blood withdrawal. Tissue samples are obtained at various time intervals for determination of antioxidant enzymes activities. Results to date indicate that superoxide dismutase activity either declines or is unchanged in plasma, myocardium, brain, large and small intestines, liver, skeletal muscle, and lung tissues. In contrast, catalase activity is induced with substantial increases in catalase activity in each of the aforementioned tissues. These results may have important implications for understanding the pathophysiology of hemorrhagic shock and consequently, in the design of therapeutic strategies for resuscitation from hemorrhagic shock. Keywords: Hemorrhagic shock. (KT)

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