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Role of Adenosine Analogs and Growth Hormone in Waking and Sleep

机译:腺苷类似物和生长激素在醒来和睡眠中的作用

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We have tried to establish the mechanism of hypnotic action of adenosine by pursuing several lines of investigation. First, we have found that when rats are deprived of rapid-eye-movement sleep (REMS) there is an increase in adenosine A1 receptors in two brain structures, the cerebral cortex and the corpus striatum. At the same time there was no change in brain adenosine concentration. Secondly, we have tested the hypothesis that hypnotic action of benzodiazepines, which block the transport of adenosine stimulation of adenosine receptors. We found that chronic administration of diazepam stimulated adenosine receptors. We found that chronic administration of diazepam stimulated adenosine receptors which was evident by a decreased number of A1 receptors in the hippocampus and A2 receptors in the striatum. Finally, we studied the effects on sleep in rats of various types of adenosine receptor stimulants and blockers and obtained results that were in accordance with our previous reports. (AW)

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