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Safety Testing of Dengue-1 and Dengue-3 Seeds for Human Challenges, Unattenuated. Dengue Virus Type 4

机译：登革1和登革3种子对人类挑战的安全性测试，未衰减。登革热病毒4型

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Dengue Virus Type 4 (CARIB 341750), Challenged Seed, non-attenuated, Lot No. 2 of Jan 1986 was safety tested in accordance with the guidelines established by the FDA for live and inactivated vaccines. The Tissue Culture Purity (Safety) tests were unsatisfactory due to the use of a hyperimmune rabbit antiserum that was subsequently found to readily hemagglutinate guinea pig RBC suggesting the presence in the serum of the a hemagglutinating agent(s). Keywords: Hepatitis A. (AW)

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作者
Potash, L.;
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年度 1988
页码 p.1-30
总页数 30
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Vaccines; Dengue; Agglutinins; Guinea pigs; Hepatitis; Inactivation; Live vaccines; Purity; Tissue culture;

机译：疫苗;登革热;凝集素;豚鼠;肝炎;灭活;活疫苗;纯度;组织培养;

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专利

1. Needle-free Biojector injection of a dengue virus type 1 DNA vaccine with human immunostimulatory sequences and the GM-CSF gene increases immunogenicity and protection from virus challenge in Aotus monkeys [J] . Kanakatte Raviprakash, Dan Ewing, Monika Simmons, Virology . 2003,第2期

机译：无针Biojector注射具有人类免疫刺激序列和GM-CSF基因的登革热病毒1型DNA疫苗，可提高免疫性并保护Aotus猴子免受病毒攻击
2. Olive baboons: a non-human primate model for testing dengue virus type 2 replication [J] . Iris Valdés, Lázaro Gil, Jorge Castro, International journal of infectious diseases : . 2013,第12期

机译：橄榄狒狒：用于测试2型登革热病毒复制的非人类灵长类动物模型
3. Clinical Phase 1 Testing of the Safety and Immunogenicity of an Epitope-Based DNA Vaccine in Human Immunodeficiency Virus Type 1-Infected Subjects Receiving Highly Active Antiretroviral Therapy [J] . Cara C. Wilson, Mark J. Newman, Brian D. Livingston, Clinical and vaccine immunology: CVI . 2008,第6期

机译：临床1期基于表位的DNA疫苗在接受高活性抗逆转录病毒治疗的人类免疫缺陷病毒1型感染受试者中的安全性和免疫原性测试
4. Simultaneous extraction of human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) RNA with the M1000 apparatus does not impair the measurement of the viral load of both viruses when tested by using the LCx PCR system [C] . T. Bourlet, S. Thamm, S. Pillet, European Congress of Virology . 2004

机译：通过使用LCX PCR系统测试，同时提取人免疫缺陷病毒类型1（HIV-1）和丙型肝炎病毒（HCV）RNA，不会损害两种病毒的病毒载量的测量
5. Complete genomic sequences of dengue-1 viruses from Paraguay and Argentina. [D] . Mantovani, Rachel Aguilar. 2004

机译：来自巴拉圭和阿根廷的登革热1病毒的完整基因组序列。
6. Epitope Determinants of a Chimpanzee Dengue Virus Type 4 (DENV-4)-Neutralizing Antibody and Protection against DENV-4 Challenge in Mice and Rhesus Monkeys by Passively Transferred Humanized Antibody [O] . Ching-Juh Lai, Ana P. Goncalvez, Ruhe Men, 2007

机译：黑猩猩登革热病毒4型（DENV-4）中和抗体的抗原决定簇和被动转移人源化抗体对小鼠和恒河猴的DENV-4攻击的保护
7. Needle-free Biojector injection of a dengue virus type 1 DNA vaccine with human immunostimulatory sequences and the GM-CSF gene increases immunogenicity and protection from virus challenge in Aotus monkeys [O] . Raviprakash Kanakatte, Ewing Dan, Simmons Monika, 2003

机译：无针Biojector注射具有人类免疫刺激序列和GM-CSF基因的登革热病毒1型DNA疫苗，可提高免疫性并保护Aotus猴子免受病毒攻击

Safety Testing of Dengue-1 and Dengue-3 Seeds for Human Challenges, Unattenuated. Dengue Virus Type 4

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