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L-Leucyl-L-Leucine Methyl Ester Treatment of Canine Marrow and Peripheral Blood Cells.

机译：L-亮氨酰-L-亮氨酸甲酯处理犬骨髓和外周血细胞。

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Incubation of canine marrow and peripheral blood mononuclear cells with L-leucyl-L-leucine methyl ester resulted in the inhibition of mitogen- and alloantigen-induced blastogenesis, the elimination of allosensitized CTL and NK activity, and prevented the development of CTL from pCTL. The effects of these incubations were similar to those described in mice and humans. Additionally, in vitro CFU-GM growth from treated canine marrow was reduced, but could be regained when the Leu-Leu-OMe-treated marrow was cocultured with either untreated autologous peripheral blood mononuclear cells or monocyte-enriched PBMC but not with untreated monocyle-depleted PBMC. Six of seven dogs conditioned with 920 cGy total-body irradiation engrafted successfully after receiving autologous marrow that was incubated with Leu-Leu-OMe prior to infusion. These cumulative results indicate that incubation with Leu-Leu-OMe is a feasible method to deplete canine marrows of alloreactive and cytotoxic T cells prior to transplantation. Reprints. (KT)

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作者
Raff, R. F.; Severns, E.; Storb, R.; Martin, P.; Graham, T.;
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年度 1988
页码 1-7
总页数 7
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Monocytes; Dogs; Humans; Immunochemistry; Biochemistry; Incubation; Mice; Nuclei; Reprints; Esters; Natural Killer Cells; L-Leucyl-L-Leucine Methyl Esters; Toxicology; Bone marrow transplantation; Blastogenesis Inhibition; Cytotoxic T lymphocytes;

机译：单核细胞;狗;人类;免疫化学;生物化学;孵育;小鼠;细胞核;重印;酯类;天然杀伤细胞; L-亮氨酰-L-亮氨酸甲酯;毒理学;骨髓移植;胚细胞生成抑制;细胞毒性T淋巴细胞;

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1. Design, synthesis, photochemical properties and cytotoxic activities of water-soluble caged L-leucyl-L-leucine methyl esters that control apoptosis of immune cells. [J] . Mizuta H, Watanabe S, Sakurai Y, Bioorganic and medicinal chemistry . 2002,第3期

机译：控制免疫细胞凋亡的水溶性笼状L-亮氨酰-L-亮氨酸甲酯的设计，合成，光化学性质和细胞毒活性。
2. Molecular cloning of the canine fragile histidine triad (FHIT) gene and fhit protein expression in canine peripheral blood mononuclear cells. [J] . Hiraoka H., Minami K., Kaneko N., The Journal of Veterinary Medical Science . 2009,第5期

机译：犬外周血单核细胞中犬脆性组氨酸三联体（ FHIT ）基因的分子克隆和fhit蛋白表达。
3. Characterization of CD34+ cells from canine umbilical cord blood, bone marrow leukocytes, and peripheral blood by flow cytometric analysis [J] . Tsumagari S, Otani I, Tanemura K, The Journal of Veterinary Medical Science . 2007,第11期

机译：流式细胞仪分析犬脐带血，骨髓白细胞和外周血CD34 +细胞的特征
4. AUTOLOGOUS PERIPHERAL BLOOD STEM CELL TRANSPLANTATION FOR THE TREATMENT OF CANINE LYMPHOMA [C] . Steven E. Suter Canadian Veterinary Medical Association Convention . 2009

机译：用于治疗犬淋巴瘤的自体外周血干细胞移植
5. Chromosomal aberrations in the tumor and peripheral blood and changes in aberrations during treatment of canine lymphoma. [D] . Devitt, Jennifer J. 2008

机译：犬淋巴瘤治疗过程中肿瘤和外周血中的染色体畸变以及畸变的变化。
6. Mechanism of L-leucyl-L-leucine methyl ester-mediated killing of cytotoxic lymphocytes: dependence on a lysosomal thiol protease dipeptidyl peptidase I that is enriched in these cells. [O] . D L Thiele, P E Lipsky 1990

机译：L-亮氨酰-L-亮氨酸甲酯介导的杀伤细胞毒性淋巴细胞的机制：依赖于溶酶体硫醇蛋白酶二肽基肽酶I该酶富集于这些细胞中。
7. Mechanism of L-leucyl-L-leucine methyl ester-mediated killing of cytotoxic lymphocytes: dependence on a lysosomal thiol protease, dipeptidyl peptidase I, that is enriched in these cells. [O] . Thiele, D L, Lipsky, P E 1990

机译：L-亮氨酰-L-亮氨酸甲酯介导的杀伤细胞毒性淋巴细胞的机制：依赖于溶酶体硫醇蛋白酶，二肽基肽酶I，该酶富集于这些细胞中。
8. L-Leucyl-L-Leucine Methyl Ester Treatment of Canine Marrow and Peripheral Blood Cells: Inhibition of Proliferative Responses with Maintenance of the Capacity for Autologous Marrow Engraftment. [R] . Raff, R. F., Severns, E., Storb, R., 1988

机译：L-亮氨酰-L-亮氨酸甲酯处理犬骨髓和外周血细胞：通过维持自体骨髓移植的能力抑制增殖反应。

L-Leucyl-L-Leucine Methyl Ester Treatment of Canine Marrow and Peripheral Blood Cells.

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