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Endogenous Opioid Peptides and Epilepsy: Quieting the Seizing Brain.

机译：内源性阿片肽和癫痫：使癫痫大脑静音。

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The brain opioid system has been implicated in the pathophysiology of seizure disorders and cellular mechanisms of epileptogenesis. while opioid peptides were originally envisioned as endogenous convulsants, a growing body of evidence demonstrates that these neuropeptides are also anticonvulsant. A role for opioid peptides as neuromodulators of postictal seizure arrest and refractories is recognized, and their endogenous activation by seizures is firmly established. Frank Tortella reviews the proconvulsant/anticonvulsant pharmacology of opioid peptides, the evidence for their involvement in postictal mechanisms, and the possible existence in the CNS of an endogenous anticonvulsant substance with opioid peptide-like characteristics. Keywords: Epilepsy; Seizures; Opioid peptides. (KT)

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Tortella, F. C.;
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年度 1988
页码 1-9
总页数 9
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Anticonvulsants; Convulsive disorders; Epilepsy; Pharmacology; Brain; Cytology; Narcotics; Therapy; Nerves; Refractory materials; Reprints; Opioid Peptides;

机译：抗惊厥药;惊厥性疾病;癫痫;药理学;脑;细胞学;麻醉品;治疗;神经;耐火材料;重印;阿片类肽;

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1. NMR studies of the structure and dynamics of peptide E, an endogenous opioid peptide that binds with high affinity to multiple opioid receptor subtypes [J] . Yan Chunhua, Guiles R.D., Digate Russell J. Biopolymers: Original Research on Biomolecules and Biomolecular Assemblies . 1999,第1期

机译：核磁共振研究肽E的结构和动力学，肽E是与多种阿片受体亚型高亲和力结合的内源性阿片肽
2. Regulation of Opioid Receptors by Their Endogenous Opioid Peptides [J] . Gupta Achla, Gullapalli Srinivas, Pan Hui, Cellular and Molecular Neurobiology . 2021,第5期

机译：其内源性阿片类药物肽调节阿片受体
3. Distinct roles of exogenous opioid agonists and endogenous opioid peptides in the peripheral control of neuropathy-triggered heat pain [J] . Dominika Labuz, Melih ?. Celik, Andreas Zimmer, Scientific reports. . 2016,第1期

机译：外源阿片类激动剂和内源性阿片类药物在神经病变触发热疼痛外周期控制中的明显作用
4. Opioid Ligand Binding to Opioid Receptors: Insight and Implications for Peptide Design [C] . Michael J. Ferracane, Jane V. Aldrich American Peptide Symposium . 2015

机译：阿片类配体与阿片受体的结合：肽设计的见解和影响
5. Exploring Opioid and Cannabis Pharmacology: Biased Signaling of Endogenous Opioid Peptides and Cannabimimetic Properties of Cannabis Sativa Terpenes [D] . LaVigne, Justin. 2020

机译：探索阿片类药物和大麻药理学：内源性阿片类药物肽的偏置信号和大麻苜蓿萜烯的大麻特性
6. The occurrence and receptor specificity of endogenous opioid peptides within the pancreas and liver of the rat. Comparison with brain. [O] . X Z Khawaja, I C Green, J R Thorpe, 1990

机译：大鼠胰腺和肝脏内源性阿片肽的发生及其受体特异性。与大脑比较。
7. The occurrence and receptor specificity of endogenous opioid peptides within the pancreas and liver of the rat. Comparison with brain. [O] . Khawaja, X Z, Green, I C, Thorpe, J R, 1990

机译：大鼠胰腺和肝脏内源性阿片肽的发生及其受体特异性。与大脑比较。

Endogenous Opioid Peptides and Epilepsy: Quieting the Seizing Brain.

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