Single-Dose Absorption and Pharmacokinetics of WR 6026. Phase 1

机译：WR 6026的单剂量吸收和药代动力学。第1阶段

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WR 6026 is a promising agent for the treatment of visceral leishmaniasis based on experiments in both an animal model and an in vitro test system. This human study was performed in order to increase our understanding of the pharmacokinetics, safety, and tolerance of a single oral 60 mg dose of WR 6026 in healthy male volunteers. Following the administration of a single dose of 60 mg of WR 6026, serial blood specimens and urine collections were obtained in order to assess the pharmacokinetics of this compound. The volunteers were monitored for subjective tolerance by daily interview and for objective toxicity with clinical laboratory tests of hematology and chemistry variables, electrocardiograms, urinalysis, and methemoglobin determinations. All of the subjects tolerated WR 6026 very well with no adverse symptoms. No subject had a significant change in hematological parameters, electrocardiograms, methemoglobin, creatine kinase or urinalysis. (kt)

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Petty, B. G.; Kornhauser, D. M.; Shapiro, T. B.; Lietman, P. S.;
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年度 1988
页码 p.1-205
总页数 205
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Drug tolerance; Leishmaniasis; Pharmacokinetics; Adverse conditions; Animals; Biological absorption; Antiparasitic drugs; Chemistry; Clinical laboratories; Collection; Creatine phosphokinase; Dosage; Electrocardiography; Hematology; Humans; In vitro analysis; Laborat;

机译：药物耐受性;利什曼病;药代动力学;不利条件;动物;生物吸收;抗寄生虫药;化学;临床实验室;收集;肌酸磷酸激酶;剂量;心电图;血液学;人类;体外分析;实验室;

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Single-Dose Absorption and Pharmacokinetics of WR 6026. Phase 1

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