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Preliminary Review of the Determinants Responsible for Virulence of Microbiological Organisms

机译：负责微生物生物毒力的决定因素初探

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Interest in the determinants of microbial pathogenicity has been revived with the goal of discovering new, more effective control, prophylactic, and therapeutic measures. Public health initiatives have controlled the worst of infectious diseases. But, in spite of major historical advances in areas such as immunology and antibiotic therapy, many problems remain. For example, no effective, broad-spectrum antiviral drug exists. There has also been a recent and alarming rise of bacterial and fungal infections in hospital patients. An understanding of factors responsible for virulence and a basic knowledge of the mechanisms of pathogenicity could provide revolutionary approaches to disease prevention, control, and therapy; and the U.S. Army Chemical Research, Development and Engineering Center (CRDEC) thrust of generically detecting human pathogenic microorganisms would be greatly enhanced.

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