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Study of Toxic and Antigenic Structures of Botulinum Neurotoxin. Final Report

机译：肉毒神经毒素的毒性和抗原结构研究。总结报告

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Procedure to purify types A, B, and E neurotoxin (NT) using FPLC was developed. The NT produced by strain B-657 was identified and characterized based on partial amino acid sequence. The heavy chains of types A, B and E NTs were enzymatically cleaved at about the mid-point. The two halves of the heavy chain of type A were isolated and partially sequenced. Specific chemical modification reactions were used to examine the role of carboxyl groups, lysine and tyrosine residues. Type B and E NTs completely detoxified following tyrosine modification were used as immunogen to raise, in rabbits, NT neutralizing antibody. Conformation of the NTs and the isolated heavy and light chains were examined by circular dichroism, fluorescence spectra and UV-difference spectra. Interaction of the subunit chains of the three NTs with lipid bilayer surface was examined. Keywords: Clostridium botulinum; Amino acid sequence. (AW)

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作者
DasGupta, B. R.;
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年度 1988
页码 p.1-17
总页数 17
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Amino acids; Antigens; Bacterial toxins; Clostridium botulinum; Antibodies; Carboxyl groups; Chemical properties; Chemical reactions; Circular; CNS depressants; Conformity; Dichroism; Fluorescence; Immunogens; Isolation; Layers; Lipids; Modification; Neutralization; Ra;

机译：氨基酸;抗原;细菌毒素;肉毒梭菌;抗体;羧基;化学特性;化学反应;环状; CNs抑制剂;符合性;二向色性;荧光;免疫原;分离;层;脂质;修饰;中和; Ra;

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Study of Toxic and Antigenic Structures of Botulinum Neurotoxin. Final Report

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