Cytotoxic Effects of Trimethylpentane on Rat Renal Tissue

机译：三甲基戊烷对大鼠肾组织的细胞毒作用

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The primary objective of the investigation was to determine the acute cytopathologic effects of 2,3,4 - trimethylpentane, a major constituent of gasoline, on renal tissue of the mature male rat. Three groups of 9 Fischer-344 rats each were administered trimethylpentane by gavage twice weekly for 7,14 or 28 days at a concentration of 1.5 mg/kg body weight. The tissues were fixed by perfusion, and subsequently processed for scanning and transmission electron microscopy. Although the manifestations of hydrocarbon toxicity were evident in all experimental tissues examined, the extent and magnitude of cellular lesions increased as the exposure period progressed. The only structural change detected within the glomerular complex was a significant increase in the number of microvilli associated with various branches of the podocytes. Cells of the proximal convoluted tubule were characterized by the presence of membrane-bound, PAS positive hyaline droplets.

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Norton, W. N.; Mattie, D. R.;
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年度 1987
页码 p.1-10
总页数 10
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Cytotoxin; Gasoline; Toxicity; Pentanes; Electron microscopy; Electronic scanners; Glomeruli; Hydrocarbons; Kidneys; Males; Modification; Perfusion; Rats; Tissues(Biology); Transmittance; Response(Biology); Physiological effects; Pathology; Reprints; Cancer; Exposure(Ph;

机译：细胞毒素;汽油;毒性;戊烷;电子显微镜;电子扫描仪;肾小球;碳氢化合物;肾;男性;修饰;灌注;大鼠;组织（生物学）;透射率;反应（生物学）;生理影响;病理学;重印;癌症;暴露（pH;

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8. Ultrastructural and Cytochemical Evaluation of the Cytotoxicities of Trimethylpentane on Rat Renal and Hepatic Tissues [R] . Norton, W. N. 1986

机译：三甲基戊烷对大鼠肾脏和肝组织细胞毒性的超微结构和细胞化学评价

Cytotoxic Effects of Trimethylpentane on Rat Renal Tissue

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